ArticleArteriosclerosis, thrombosis, and vascular biology2014
Differences in vascular nitric oxide and endothelium-derived hyperpolarizing factor bioavailability in blacks and whites.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00166166 (Physiology and Pathologic Role of Endothelium-Derived Hyperpolarizing Factor in Humans), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiology and Pathologic Role of Endothelium-Derived Hyperpolarizing Factor in Humans
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
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- Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Molecular crosstalk in perivascular adipose tissue: mechanisms of inflammation, metabolic dysregulation, and therapeutic opportunities in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
- Complete autonomic blockade reveals nitric oxide contribution to blood pressure regulation in obese Black women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- The effect of endothelin a receptor inhibition and biological sex on cutaneous microvascular function in non-Hispanic Black and White young adults.Physiological reports · 2024Article
- Inhibition of superoxide and iNOS augment cutaneous nitric oxide-dependent vasodilation in non-Hispanic black young adults.Physiological reports · 2024Article
- Contribution of sensory nerves to cutaneous reactive hyperaemia in non-Hispanic Black and White young adults.Experimental physiology · 2023Article
- Racial Differences in Blood Pressure and Autonomic Recovery Following Acute Supramaximal Exercise in Women.International journal of environmental research and public health · 2023Article
- Endothelin A receptor inhibition increases nitric oxide-dependent vasodilation independent of superoxide in non-Hispanic Black young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The peripheral vascular responses in non-freezing cold injury and matched controls.Experimental physiology · 2023Article
- The Impact of Health Care Disparities on Patients With Heart Failure.Journal of cardiac failure · 2022Review
- Evidence of reduced peripheral microvascular function in young Black women across the menstrual cycle.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Diabetes pathogenesis and management: the endothelium comes of age.Journal of molecular cell biology · 2021Article
- Dose-effect relation between regular consumption of 100% cocoa powder and blood pressure in young, healthy black Africans.Physiological reports · 2021Article
- Young black women demonstrate impaired microvascular but preserved macrovascular function compared to white women.Experimental physiology · 2021Article
- Weekly Physiological Changes in Blood Pressure During Three Weeks Daily Consumption of 10 Grams of Cocoa Powder Among Young Black Africans in Côte d'Ivoire.Frontiers in physiology · 2021Article
- Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAbnormalities in nitric oxide (NO) bioavailability have been reported in blacks. Whether there are differences in endothelium-derived hyperpolarizing factor (EDHF) in addition to NO between blacks and whites and how these affect physiological vasodilation remain unknown. We hypothesized that the bioavailability of vascular NO and EDHF, at rest and with pharmacological and physiological vasodilation, varies between whites and blacks. APPROACH AND
resultsIn 74 white and 86 black subjects without known cardiovascular disease risk factors, forearm blood flow was measured using plethysmography at rest and during inhibition of NO with N(G)-monomethyl-L-arginine and of K(+) Ca channels (EDHF) with tetraethylammonium. The reduction in resting forearm blood flow was greater with N(G)-monomethyl-L-arginine (P=0.019) and similar with tetraethylammonium in whites compared with blacks. Vasodilation with bradykinin, acetylcholine, and sodium nitroprusside was lower in blacks compared with whites (all P<0.0001). Inhibition with N(G)-monomethyl-L-arginine was greater in whites compared with blacks with bradykinin, acetylcholine, and exercise. Inhibition with tetraethylammonium was lower in blacks with bradykinin, but greater during exercise and with acetylcholine.
conclusionsThe contribution to both resting and stimulus-mediated vasodilator tone of NO is greater in whites compared with blacks. EDHF partly compensates for the reduced NO release in exercise and acetylcholine-mediated vasodilation in blacks. Preserved EDHF but reduced NO bioavailability and sensitivity characterizes the vasculature in healthy blacks. CLINICAL TRIAL REGISTRATION URL: http://clinicaltrials.gov/. Unique identifier: NCT00166166.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.