ArticleCell death & disease2014
Survivin is essential for fertile egg production and female fertility in mice.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- Clinical and Molecular Effects of GnRH Agonist and Antagonist on The Cumulus Cells in TheInternational journal of fertility & sterility · 2021Article
- Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice.Frontiers in cell and developmental biology · 2021Article
- Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice.Cell death and differentiation · 2019Article
- CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.The EMBO journal · 2018Article
- Transcriptome sequencing reveals key potential long non-coding RNAs related to duration of fertility trait in the uterovaginal junction of egg-laying hens.Scientific reports · 2018Article
- Survivin regulates chromosome segregation by modulating the phosphorylation of Aurora B during porcine oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2018Article
- Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.Cell death & disease · 2017Article
- Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion.Molecular human reproduction · 2016Article
- Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice.Current biology : CB · 2016Article
- Article
- MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.Autophagy · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survivin is the smallest member of the inhibitor of apoptosis protein (IAP) family and acts as a bifunctional protein involved in mitosis regulation and apoptosis inhibition. To identify the physiological role of Survivin in female reproduction, we selectively disrupted Survivin expression in oocytes and granulosa cells (GCs), two major cell types in the ovary, by two different Cre-Loxp conditional knockout systems, and found that both led to defective female fertility. Survivin deletion in oocytes did not affect oocyte growth, viability and ovulation, but caused tetraploid egg production and thus female infertility. Further exploration revealed that Survivin was essential for regulating proper meiotic spindle organization, spindle assembly checkpoint activity, timely metaphase-to-anaphase transition and cytokinesis. Mutant mice with Survivin depleted in GCs showed reduced ovulation and subfertility, caused by defective follicular growth, increased follicular atresia and impaired luteinization. These findings suggest that Survivin has an important role in regulating folliculogenesis and oogenesis in the adult mouse ovary.
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