Evidence map›Paper›PMID 24675231›Full record

ReviewBeneficial microbes2014

Probiotic 'glow of health': it's more than skin deep.

S E Erdman, T Poutahidis

Registry-linked trialAbstract readReview
In one paragraph

Review in Beneficial microbes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03210779 (Effect of Probiotic Tablets and Topical Probiotic Oil), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03210779 nacompletednot on this mapstarted 2016, after this paper: background citation

Effect of Probiotic Tablets and Topical Probiotic Oil (Lactobacillus. Reuteri) on Oral Wound Healing (Pilot Study)

TypeinterventionalSponsorUniversity of CopenhagenRan2016 to 2017Enrolled10ConditionsWoundArmsL. reuteri DSM 17938/ATCC PTA, Placebo
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Oral Probiotics inMedicina (Kaunas, Lithuania) · 2025
    Pooled it
  2. Microbial lysate upregulates host oxytocin.Brain, behavior, and immunity · 2017
    Trial
  3. Article
  4. Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine- and enterocyte-derived hormones.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. bioRxiv : the preprint server for biology · 2024
    Article
  6. [Research progress on the mechanisms of probiotics promoting wound healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Effects of Dietary Supplementation ofAnimals : an open access journal from MDPI · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Microorganisms' Footprint in Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2018
    Review
  18. Anxiety, Depression, and the Microbiome: A Role for Gut Peptides.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  19. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S E ErdmanDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
T PoutahidisDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Faculty of Veterinary Medicine, Laboratory of Pathology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
GI Tract Dysbiosis and Breast CancerU01CA164337 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E, WANG, TIMOTHY CRAGIN · 2012 to 2016
$2.6M
Role of IL10 and TGFb1 in colon cancerR01CA108854 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E · 2005 to 2014
$2.4M
NCI NIH HHS R01 CA108854NCI NIH HHS R01CA108854NCI NIH HHS U01 CA164337NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P30-ES002109
6 · The paper itself

Abstract

Radiant skin and hair are universal indicators of good health. It was recently shown that feeding of probiotic bacteria to aged mice rapidly induced youthful vitality characterised by thick lustrous skin and hair, and enhanced reproductive fitness, not seen in untreated controls. Probiotic-treated animals displayed integrated immune and hypothalamic-pituitary outputs that were isolated mechanistically to microbe-induced anti-inflammatory interleukin-10 and neuropeptide hormone oxytocin. In this way, probiotic microbes interface with mammalian physiological underpinnings to impart superb physical and reproductive fitness displayed as radiant and resilient skin and mucosae, unveiling novel strategies for integumentary health.

Indexed as

Skin Physiological PhenomenaAnimalsInterleukinsMiceOxytocinProbioticsSkin DiseasesInterleukinsOxytocininflammationLactobacillus reuteriprobioticsregulatory T cells

Identifiers

PMID24675231
PMCPMC4354898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.