ArticleBrain, behavior, and immunity2014
Childhood environments and cytomegalovirus serostatus and reactivation in adults.
Article in Brain, behavior, and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- CMV primary and non-primary infections among daycare workers, and development of strategies to prevent infection (EDUQ-CMV): a mixed-method study protocol.BMC infectious diseases · 2025Observational
- The embodiment of the neighborhood socioeconomic environment in the architecture of the immune system.PNAS nexus · 2024Article
- Lifespan Socioeconomic Context Is Associated With Cytomegalovirus and Late-Differentiated CD8 + T and Natural Killer Cells: Initial Results in Older Adults.Psychosomatic medicine · 2024Article
- The association between incarceration and housing insecurity and advanced immune age during late life.Social science & medicine (1982) · 2024Article
- Exposure, Susceptibility, and Recovery: A Framework for Examining the Intersection of the Social and Physical Environments and Infectious Disease Risk.American journal of epidemiology · 2023Article
- Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health.Current topics in behavioral neurosciences · 2023Article
- A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder.Molecular psychiatry · 2021Article
- Life Course Socioeconomic Disadvantage and the Aging Immune System: Findings From the Health and Retirement Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Early life predictors of positive change during the coronavirus disease pandemic.BMC psychology · 2021Article
- Racial disparities in sleep health between Black and White young adults: The role of neighborhood safety in childhood.Sleep medicine · 2021Article
- Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan.Frontiers in psychology · 2021Review
- How does the social world shape health across the lifespan? Insights and new directions.The American psychologist · 2020Article
- A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis.SSM - population health · 2020Review
- Race/Ethnic and Educational Disparities in the Association Between Pathogen Burden and a Laboratory-Based Cumulative Deficits Index.Journal of racial and ethnic health disparities · 2020Article
- Understanding the intersection of race and place: the case of tuberculosis in Michigan.BMC public health · 2019Article
- Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder.JAMA psychiatry · 2019Article
- Early childhood family instability and immune system dysregulation in adolescence.Psychoneuroendocrinology · 2019Article
- Socioeconomic status and central adiposity as determinants of stress-related biological responses relevant to cardiovascular disease risk.Brain, behavior, and immunity · 2019Article
- Persistent skewing of the T-cell profile in adolescents adopted internationally from institutional care.Brain, behavior, and immunity · 2019Article
- Social patterning of acute respiratory illnesses in the Household Influenza Vaccine Evaluation (HIVE) Study 2014-2015.Epidemiology and infection · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Childhood adversity, defined in terms of material hardship or physical or emotional maltreatment has been associated with risk for infection with cytomegalovirus (CMV) among children and adolescents, and with CMV reactivation in children and adults. The present study examined whether different dimensions of childhood experience-those pertaining to socioeconomic status (SES), physical environment, or family relationships-relate differentially to CMV serostatus and reactivation during adulthood. Participants were 140 healthy adults, aged 18-55years (41% female; 64% white). Childhood environments were assessed retrospectively and included family SES (parental housing tenure); childhood neighborhood environment (urban residence; physical conditions; safety; and social atmosphere); residential exposures (parental smoking and physical condition of home); and family relationships (parental divorce; warmth; harmony; dysfunction; parental bonding). Approximately 39% (n=53) of participants were CMV+. In individual analyses controlling for age, sex, race, body mass, current adult SES and smoking status, fewer years of parental home ownership, having a parent who smoked, and living in a poorly maintained or unsafe neighborhood each were associated with greater odds of infection with CMV. By comparison, in individual analyses limited to CMV+ participants, less family warmth, less harmony, greater dysfunction, and suboptimal parental bonding each were related to higher antibody levels, independent of the aforementioned covariates. Findings were not attributable to current adult perceptions of psychological stress or relative levels of emotional stability. These results suggest that different types of childhood adversity may be associated with differential effects on CMV infection and latency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.