Evidence map›Paper›PMID 24674979›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2014

Acute drop in blood monocyte count differentiates NEC from other causes of feeding intolerance.

J Remon, R Kampanatkosol, R R Kaul, J K Muraskas, R D Christensen, A Maheshwari

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 51 citations in OpenAlex.

  1. Necrotizing enterocolitis.Nature reviews. Disease primers · 2026
    Review
  2. Review
  3. Review
  4. Article
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  7. Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  8. Article
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  12. Gestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
    Article
  13. Review
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  16. Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

J Remon1] Division of Neonatology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA  [2] Center for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA.
R KampanatkosolDepartment of Pediatrics, Division of Neonatology, Loyola University Stritch School of Medicine, Maywood, IL, USA.
R R KaulCenter for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA.
J K MuraskasDepartment of Pediatrics, Division of Neonatology, Loyola University Stritch School of Medicine, Maywood, IL, USA.
R D Christensen1] Intermountain Healthcare Women and Newborns Clinical Program, Ogden, UT, USA [2] McKay-Dee Hospital Center, Ogden, UT, USA.
A Maheshwari1] Division of Neonatology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA  [2] Center for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA [3] Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USLoyola University Chicago · USIntermountain Healthcare · US

Funding

Role of Transforming Growth Factor-beta in Neonatal Necrotizing EnterocolitisR01HD059142 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAHESHWARI, AKHIL · 2009 to 2013
$1.7M
NICHD NIH HHS R01 HD059142NICHD NIH HHS R01HD059142
6 · The paper itself

Abstract

objectiveNecrotizing enterocolitis (NEC) is characterized by macrophage infiltration into affected tissues. Because intestinal macrophages are derived from recruitment and in situ differentiation of blood monocytes in the gut mucosa, we hypothesized that increased recruitment of monocytes to the intestine during NEC reduces the blood monocyte concentration and that this fall in blood monocytes can be a useful biomarker for NEC. STUDY

designWe reviewed medical records of very-low-birth-weight (VLBW) infants treated for NEC and compared them with a matched control group comprised of infants with feeding intolerance but no signs of NEC. Clinical characteristics and absolute monocyte counts (AMCs) were recorded. Diagnostic accuracy of AMC values was tested using receiver-operator characteristics (ROC).

resultWe compared 69 cases and 257 controls (median 27 weeks, range 26 to 29 in both the groups). In stage II NEC, AMCs decreased from median 1.7 × 10(9) l(-1) (interquartile range (IQR) 0.98 to 2.4) to 0.8 (IQR 0.62 to 2.1); P < 0.05. In stage III NEC, monocyte counts decreased from median 2.1 × 10(9) l(-1) (IQR 0.1.5 to 3.2) to 0.8 (IQR 0.6 to 1.9); P < 0.05. There was no change in AMCs in control infants. ROC of AMC values showed a diagnostic accuracy (area under the curve) of 0.76. In a given infant with feeding intolerance, a drop in AMCs of > 20% indicated NEC with sensitivity of 0.70 (95% confidence interval (CI) 0.57 to 0.81) and specificity of 0.71 (95% CI 0.64 to 0.77).

conclusionWe have identified a fall in blood monocyte concentration as a novel biomarker for NEC in VLBW infants.

Indexed as

BiomarkersCase-Control StudiesDiagnosis, DifferentialEnterocolitis, NecrotizingFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightLeukocyte CountMaleMonocytesRetrospective StudiesSensitivity and SpecificityBiomarkers

Identifiers

PMID24674979
PMCPMC4074443
OpenAlexW1963642716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.