ArticleMedicine and science in sports and exercise2014
Effects of substituting sedentary time with physical activity on metabolic risk.
Article in Medicine and science in sports and exercise, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Is objectively measured light-intensity physical activity associated with health outcomes after adjustment for moderate-to-vigorous physical activity in adults? A systematic review.The international journal of behavioral nutrition and physical activity · 2018Pooled it
- Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial.BMC medicine · 2021Trial
- Associations of Physical Behaviours and Behavioural Reallocations with Markers of Metabolic Health: A Compositional Data Analysis.International journal of environmental research and public health · 2018Trial
- Trial
- Trial
- Trial
- Patterns of impact resulting from a 'sit less, move more' web-based program in sedentary office employees.PloS one · 2015Trial
- Isotemporal substitution of sedentary time with physical activity for cardiovascular health in older adults: a systematic review.Frontiers in sports and active living · 2026Review
- Review
- Physical activity, sedentary behavior, and metabolic syndrome in adults with arthritis: cross-sectional and Mendelian randomization analysis.Journal of exercise rehabilitation · 2025Article
- Differences of Sedentary Behavior, Physical Activity, and Metabolic Syndrome Severity Among Metabolic Syndrome Clusters.American journal of lifestyle medicine · 2025Article
- Article
- Effectiveness of implementing evidence-based approaches to promote physical activity in a Midwestern micropolitan area using a quasi-experimental hybrid type I study design.BMC public health · 2024Article
- Impact of Replacing Sedentary Behavior with Physical Activity and Sleep on Stroke Risk: A Prospective Cohort Study.Nature and science of sleep · 2024Article
- Accelerometer-Measured Physical Activity Data Sets (Global Physical Activity Data Set Catalogue) That Include Markers of Cardiometabolic Health: Systematic Scoping Review.Journal of medical Internet research · 2023Article
- Substituting device-measured sedentary time with alternative 24-hour movement behaviours: compositional associations with adiposity and cardiometabolic risk in the ORISCAV-LUX 2 study.Diabetology & metabolic syndrome · 2023Article
- Substituting sedentary time with sleep or physical activity and subsequent weight-loss maintenance.Obesity (Silver Spring, Md.) · 2023Article
- Replacing Sedentary Time with Physically Active Behaviour Predicts Improved Body Composition and Metabolic Health Outcomes.International journal of environmental research and public health · 2022Article
- Association of sedentary behaviour and physical activity with cardiometabolic health in Japanese adults.Scientific reports · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeThe detrimental effects of sedentary time on health may act by replacing time spent in physical activities. The aim of this study was to examine cross-sectional associations between objectively assessed sedentary and physical activity domains and cardiometabolic risk factors using a novel isotemporal substitution paradigm.
methodsParticipants were 445 healthy men and women (mean age, 66 ± 6 yr), without history or objective signs of cardiovascular disease, drawn from the Whitehall II epidemiological cohort. Physical activity was objectively measured using accelerometers (ActiGraph GT3X) worn around the waist during waking hours for 4-7 consecutive days. We examined the effects of replacing sedentary time with light activity or moderate-to-vigorous physical activity (MVPA) on a range of risk factors (HDL cholesterol, triglycerides, HbA1c, and body mass index) using an isotemporal substitution paradigm.
resultsIn partition models, where the time in each of the intensity categories was held constant, only MVPA remained associated with risk factors. In isotemporal substitution models that held total (wear) time constant, replacing 10-min sedentary time with an equal amount of MVPA was associated with favorable effects in all risk factors, including HbA1c (B = -0.023; 95% confidence interval (CI), -0.043 to -0.002), BMI (B = -0.39; 95% CI, -0.54 to -0.24), HDL cholesterol (B = 0.037; 95% CI, 0.021-0.054), and triglycerides (B = -0.035; 95% CI, -0.061 to -0.009).
conclusionsThe associations between sedentary behavior and cardiometabolic risk may be dependent on the types of activities that are displaced by sedentary time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.