ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- The effects of high-intensity interval training and Iranian propolis extract on serum levels of TRPV4 and CYP2E1 proteins in patients with nonalcoholic fatty liver.La Tunisie medicale · 2024Trial
- GDF15 associates with, but is not responsible for, exercise-induced increases in corticosterone and indices of lipid utilization in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans.Frontiers in endocrinology · 2022Article
- Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity.International journal of molecular sciences · 2020Review
- Exercise-Induced Adaptations to Adipose Tissue Thermogenesis.Frontiers in endocrinology · 2020Review
- Sleep and body temperature in TNFα knockout mice: The effects of sleep deprivation, β3-AR stimulation and exogenous TNFα.Brain, behavior, and immunity · 2019Article
- Physical Activity Induces Nucleus Accumbens Genes Expression Changes Preventing Chronic Pain Susceptibility Promoted by High-Fat Diet and Sedentary Behavior in Mice.Frontiers in neuroscience · 2019Article
- Exercise activates vagal induction of dopamine and attenuates systemic inflammation.Brain, behavior, and immunity · 2019Article
- Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis.The Journal of physiology · 2018Article
- Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.Adipocyte · 2018Article
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.The Journal of endocrinology · 2017Article
- The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses.Scientific reports · 2017Article
- Estradiol does not directly regulate adipose lipolysis.Adipocyte · 2017Article
- Habitual physical activity protects against lipopolysaccharide-induced inflammation in mouse adipose tissue.Adipocyte · 2017Article
- "Weighing" the effects of exercise and intrinsic aerobic capacity: are there beneficial effects independent of changes in weight?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Review
- Prior exercise training blunts short-term high-fat diet-induced weight gain.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue.American journal of physiology. Cell physiology · 2016Article
- Statin Therapy Alters Lipid Storage in Diabetic Skeletal Muscle.Frontiers in endocrinology · 2016Article
- Effects of treadmill running and rutin on lipolytic signaling pathways and TRPV4 protein expression in the adipose tissue of diet-induced obese mice.Journal of physiology and biochemistry · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise training reduces systemic and adipose tissue inflammation. However, these beneficial effects seem to be largely tied to reductions in adipose tissue mass. The purpose of the present study was to determine if exercise training confers a protective effect against an acute inflammatory challenge. We hypothesized that the induction of inflammatory markers, such as interleukin 6 (IL-6), suppressor of cytokine signaling 3 (SOCS3), and TNF-α by the beta-3 adrenergic agonist CL 316,243 would be reduced in adipose tissue from trained mice and this would be associated with reductions in transient receptor potential cation channel 4 (TRPV4), a protein recently shown to regulate the expression of proinflammatory cytokines. Exercise training (4 wk of treadmill running, 1 h/day, 5 days/wk) increased markers of skeletal muscle mitochondrial content and the induction of PPAR-gamma coactivator 1 alpha in epididymal adipose tissue. The mRNA expression of IL-6, SOCS3, and TNFα were not different in subcutaneous and epididymal adipose tissue from sedentary and trained mice; however, the CL 316,243-mediated induction of these genes was attenuated ∼50% in epididymal adipose tissue from trained mice as were increases in plasma IL-6. The effects of training were not explained by reductions in lipolytic responsiveness, but were associated with decreases in TRPV4 protein content. These results highlight a previously unappreciated anti-inflammatory effect of exercise training on adipose tissue immunometabolism and underscores the value of assessing adipose tissue inflammation in the presence of an inflammatory insult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.