ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
The role of muscle mass in exercise-induced hyperemia.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Associations of noninvasive measures of adiposity with aortic stiffness and microvascular function: The Jackson Heart Study.American journal of preventive cardiology · 2026Article
- Dietary habits and self-reported hypoxic events in competitive freedivers: an observational study.Frontiers in nutrition · 2026Article
- α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- Toward human-like adaptability in robotics through a retention-engineered synaptic control system.Science advances · 2024Article
- Dietary nitrate supplementation and small muscle mass exercise hemodynamics in patients with essential hypertension.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Variability in the Aerobic Fitness-Related Dependence on Respiratory Processes During Muscle Work Is Associated With the ACE-I/D Genotype.Frontiers in sports and active living · 2022Article
- Heart failure with preserved ejection fraction diminishes peripheral hemodynamics and accelerates exercise-induced neuromuscular fatigue.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- α-Adrenergic receptor regulation of skeletal muscle blood flow during exercise in heart failure patients with reduced ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Sex-specific impact of aging on the blood pressure response to exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Post-exercise blood flow restriction attenuates hyperemia similarly in males and females.European journal of applied physiology · 2017Article
- Exercise-induced brachial artery blood flow and vascular function is impaired in systemic sclerosis.American journal of physiology. Heart and circulatory physiology · 2016Article
- Impaired skeletal muscle vasodilation during exercise in heart failure with preserved ejection fraction.International journal of cardiology · 2016Article
- Symmorphosis and skeletal muscle V̇O2 max : in vivo and in vitro measures reveal differing constraints in the exercise-trained and untrained human.The Journal of physiology · 2016Article
- Reliability of a Novel High Intensity One Leg Dynamic Exercise Protocol to Measure Muscle Endurance.PloS one · 2016Article
- Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase.European journal of applied physiology · 2015Article
- Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Exercise-induced hyperemia is often normalized for muscle mass, and this value is sometimes evaluated at relative exercise intensities to take muscle recruitment into account. Therefore, this study sought to better understand the impact of muscle mass on leg blood flow (LBF) during exercise. LBF was assessed by Doppler ultrasound in 27 young healthy male subjects performing knee-extensor (KE) exercise at three absolute (5, 15, and 25 W) and three relative [20, 40, and 60% of maximum KE (KEmax)] workloads. Thigh muscle mass (5.2-8.1 kg) and LBF were significantly correlated at rest (r = 0.54; P = 0.004). Exercise-induced hyperemia was linearly related to absolute workload, but revealed substantial between-subject variability, documented by the coefficient of variation (5 W: 17%; 15 W: 16%; 25 W: 16%). Quadriceps muscle mass (1.5-2.7 kg) and LBF were not correlated at 5, 15, or 25 W (r = 0.09-0.01; P = 0.7-0.9). Normalizing blood flow for quadriceps muscle mass did not improve the coefficient of variation at each absolute workload (5 W: 21%; 15 W: 21%; 25 W: 22%), while the additional evaluation at relative exercise intensities resulted in even greater variance (20% KEmax: 29%; 40% KEmax: 29%; 60% KEmax: 27%). Similar findings were documented when subjects were parsed into high and low aerobic capacity. Thus, in contrast to rest, blood flow during exercise is unrelated to muscle mass, and simply normalizing for muscle mass or comparing normalized blood flow at a given relative exercise intensity has no effect on the inherent blood flow variability. Therefore, during exercise, muscle mass does not appear to be a determinant of the hyperemic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.