Case study: polycystic livers in a transgenic mouse line.

Jamie Lovaglio, James E Artwohl, Christopher J Ward, Thomas Gh Diekwisch, Yoshihiro Ito, Jeffrey D Fortman

Open access · greenAbstract readCase Reports

In one paragraph

Article in Comparative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 95% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jamie LovaglioBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.

James E ArtwohlBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA. Jeart@uic.edu.

Christopher J WardMayo Clinic, Rochester, Maine, USA.

Thomas Gh DiekwischDepartment of Oral Biology, University of Illinois at Chicago, Chicago, Illinois, USA.

Yoshihiro ItoDepartment of Oral Biology, University of Illinois at Chicago, Chicago, Illinois, USA.

Jeffrey D FortmanBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.

University of Illinois Chicago · US

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI ROMERO, MICHAEL F. · 2010 to 2019

$11.8M

6 · The paper itself

Abstract

Three mice (2 male, 1 female; age, 5 to 16 mo) from a mouse line transgenic for keratin 14 (K14)-driven LacZ expression and on an outbred Crl:CD1(ICR) background, were identified as having distended abdomens and livers that were diffusely enlarged by numerous cysts (diameter, 0.1 to 2.0 cm). Histopathology revealed hepatic cysts lined by biliary type epithelium and mild chronic inflammation, and confirmed the absence of parasites. Among 21 related mice, 5 additional affected mice were identified via laparotomy. Breeding of these 5 mice (after 5 mo of age) did not result in any offspring; the K14 mice with polycystic livers failed to reproduce. Affected male mice had degenerative testicular lesions, and their sperm was immotile. Nonpolycystic K14 control male mice bred well, had no testicular lesions, and had appropriate sperm motility. Genetic analysis did not identify an association of this phenotype with the transgene or insertion site.

Indexed as

Mice, TransgenicAnimalsCystsDNA PrimersFemaleInfertility, MaleKeratin-14LaparotomyLiver DiseasesMaleMicePolymerase Chain ReactionRodent DiseasesTestisDNA PrimersKeratin-14Krt14 protein, mouse

Identifiers

PMID24674586

PMCPMC3997289

OpenAlexW1674158922

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.