ArticleThe European journal of neuroscience2014
Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain.Nature communications · 2026Article
- The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A molecular mechanism mediating clozapine-enhanced sensorimotor gating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.Scientific reports · 2022Article
- Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia CaNeurochemical research · 2021Article
- Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.Movement disorders : official journal of the Movement Disorder Society · 2019Article
- Nitrogen gas produces less behavioural and neurophysiological excitation than carbon dioxide in mice undergoing euthanasia.PloS one · 2019Article
- A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.Current biology : CB · 2018Article
- Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.Current biology : CB · 2018Article
- Oral Delivered Dexmedetomidine Promotes and Consolidates Non-rapid Eye Movement Sleep via Sleep-Wake Regulation Systems in Mice.Frontiers in pharmacology · 2018Article
- Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.Frontiers in neural circuits · 2018Review
- A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.Scientific reports · 2016Article
- Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.Nature neuroscience · 2015Article
- Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The claustrum and consciousness: An update.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
How external stimuli prevent the onset of sleep has been little studied. This is usually considered to be a non-specific type of phenomenon. However, the hypnotic drug dexmedetomidine, an agonist at α2 adrenergic receptors, has unusual properties that make it useful for investigating this question. Dexmedetomidine is considered to produce an 'arousable' sleep-like state, so that patients or animals given dexmedetomidine become alert following modest stimulation. We hypothesized that it might be more difficult to make mice unconscious with dexmedetomidine if there was a sufficient external stimulus. Employing a motorized rotating cylinder, which provided a continuous and controlled arousal stimulus, we quantitatively measured the ability of such a stimulus to prevent dexmedetomidine loss of righting reflex in two inbred strains of mice (C57BL/6 and 129X1). We found that whereas the C57BL/6 strain required a strong stimulus to prevent dexmedetomidine-induced hypnosis, the 129X1 strain stayed awake even with minimal stimuli. Remarkably, this could be calibrated as a simple threshold trait, i.e. a binary 'yes-no' response, which after crossing the two mouse strains behaved as a dominant-like trait. We carried out a genome-wide linkage analysis on the F2 progeny to determine if the ability of a stimulus to prevent dexmedetomidine hypnosis could be mapped to one or more chromosomal regions. We identified a locus on chromosome 4 with an associated Logarithm of Odds score exceeding the pre-established threshold level. These results show that complex traits, such as the ability of a stimulus to reverse drug-induced hypnosis, may have precise genetic determinants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.