Evidence map›Paper›PMID 24673906›Full record

ReviewJournal of food and drug analysis2014

Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides.

Haohao Wu, Jun-Jie Yin, Wayne G Wamer, Mingyong Zeng, Y Martin Lo

Abstract readReview
In one paragraph

Review in Journal of food and drug analysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Nanotechnology for the treatment of iron deficiency anemia: an in vivo review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Triple composite based on metal-organic framework: differences in production of reactive oxygen species in biological and non-biological media.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Nano-delivery platforms for bacterial gene transformation: suitability and challenges.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Functionalized Magnetic FeInternational journal of molecular sciences · 2024
    Article
  18. Article
  19. Nanoparticles at the maternal-fetal interface.Molecular and cellular endocrinology · 2023
    Review
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haohao WuCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province 266003, China; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
Jun-Jie YinCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA. Electronic address: junjie.yin@fda.hhs.gov.
Wayne G WamerCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
Mingyong ZengCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province 266003, China.
Y Martin LoDepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano-iron metal and nano-iron oxides are among the most widely used engineered and naturally occurring nanostructures, and the increasing incidence of biological exposure to these nanostructures has raised concerns about their biotoxicity. Reactive oxygen species (ROS)-induced oxidative stress is one of the most accepted toxic mechanisms and, in the past decades, considerable efforts have been made to investigate the ROS-related activities of iron nanostructures. In this review, we summarize activities of nano-iron metal and nano-iron oxides in ROS-related redox processes, addressing in detail the known homogeneous and heterogeneous redox mechanisms involved in these processes, intrinsic ROS-related properties of iron nanostructures (chemical composition, particle size, and crystalline phase), and ROS-related bio-microenvironmental factors, including physiological pH and buffers, biogenic reducing agents, and other organic substances.

Indexed as

Ferric CompoundsIronAnimalsCellular MicroenvironmentHumansMetal NanoparticlesOxidation-ReductionOxidative StressReactive Oxygen SpeciesFerric Compoundsferric oxideIronReactive Oxygen SpeciesIron oxideMetallic ironNanoparticleReactive oxygen speciesToxicity

Identifiers

PMID24673906
PMCPMC9359154

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.