ArticleBMC genomics2014
Deleted copy number variation of Hanwoo and Holstein using next generation sequencing at the population level.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock.Animal biotechnology · 2025Article
- Genome-wide copy number variation regions in indigenous (Bos indicus) cattle breeds of Tamil Nadu, India.Animal bioscience · 2025Article
- Structural variant landscapes reveal convergent signatures of evolution in sheep and goats.Genome biology · 2024Article
- Detection and characterization of copy number variation in three differentially-selected Nellore cattle populations.Frontiers in genetics · 2024Article
- Evidence for early domestic yak, taurine cattle, and their hybrids on the Tibetan Plateau.Science advances · 2023Article
- Evolutionary origin of genomic structural variations in domestic yaks.Nature communications · 2023Article
- Analysis of physicochemical properties of dry-cured beef made from Hanwoo and Holstein meat distributed in South Korea.Heliyon · 2023Article
- Lectin histochemistry of the olfactory mucosa of Korean native cattle,Journal of veterinary science · 2022Article
- Ruminant-specific retrotransposons shape regulatory evolution of bovine immunity.Genome research · 2022Article
- Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning.International journal of molecular sciences · 2022Article
- Identification of Candidate Genes Regulating Carcass Depth and Hind Leg Circumference in Simmental Beef Cattle Using Illumina Bovine Beadchip and Next-Generation Sequencing Analyses.Animals : an open access journal from MDPI · 2022Article
- Mitonuclear incompatibility as a hidden driver behind the genome ancestry of African admixed cattle.BMC biology · 2022Article
- Kouprey (iScience · 2021Article
- Local adaptations of Mediterranean sheep and goats through an integrative approach.Scientific reports · 2021Article
- Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle.Genes · 2021Article
- Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia.Molecular biology and evolution · 2021Article
- The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism.Nature genetics · 2020Article
- Identification and validation of a novel candidate gene regulating net meat weight in Simmental beef cattle based on imputed next-generation sequencing.Cell proliferation · 2020Article
- BGVD: An Integrated Database for Bovine Sequencing Variations and Selective Signatures.Genomics, proteomics & bioinformatics · 2020Article
- RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef.PloS one · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCopy number variation (CNV), a source of genetic diversity in mammals, has been shown to underlie biological functions related to production traits. Notwithstanding, there have been few studies conducted on CNVs using next generation sequencing at the population level.
resultsIllumina NGS data was obtained for ten Holsteins, a dairy cattle, and 22 Hanwoo, a beef cattle. The sequence data for each of the 32 animals varied from 13.58-fold to almost 20-fold coverage. We detected a total of 6,811 deleted CNVs across the analyzed individuals (average length = 2732.2 bp) corresponding to 0.74% of the cattle genome (18.6 Mbp of variable sequence). By examining the overlap between CNV deletion regions and genes, we selected 30 genes with the highest deletion scores. These genes were found to be related to the nervous system, more specifically with nervous transmission, neuron motion, and neurogenesis. We regarded these genes as having been effected by the domestication process. Further analysis of the CNV genotyping information revealed 94 putative selected CNVs and 954 breed-specific CNVs.
conclusionsThis study provides useful information for assessing the impact of CNVs on cattle traits using NGS at the population level.
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