ArticleMolecular microbiology2014
OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 98 citations in OpenAlex.
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- Phage host interactions reveal LPS and OmpA as receptors for two Erwinia amylovora phages.Scientific reports · 2025Article
- Interplay Between Bacterial Extracellular Vesicles and Phages: Receptors, Mechanisms, and Implications.Viruses · 2025Review
- Moo19 and B2: Structures ofScience advances · 2024Article
- Viral Genome Delivery Across Bacterial Cell Surfaces.Annual review of microbiology · 2024Review
- Bacteriophage as a potential biotherapeutics to combat present-day crisis of multi-drug resistant pathogens.Heliyon · 2024Review
- Phenotypic Changes in Phage Survivors of Multidrug-ResistantIndian journal of microbiology · 2024Article
- Diversity and phage sensitivity to phages of porcine enterotoxigenicApplied and environmental microbiology · 2024Article
- Cryo-EM structure of a Shigella podophage reveals a hybrid tail and novel decoration proteins.Structure (London, England : 1993) · 2024Article
- Binding activity and specificity of tail fiber protein 35Q forFrontiers in microbiology · 2024Article
- Bacterial Virus Forcing of Bacterial O-Antigen Shields: Lessons from Coliphages.International journal of molecular sciences · 2023Review
- High-resolution cryo-EM structure of theScience advances · 2022Article
- Efficacy of Repeated Applications of Bacteriophages onPathogens (Basel, Switzerland) · 2022Article
- RB49-like Bacteriophages Recognize O Antigens as One of the Alternative Primary Receptors.International journal of molecular sciences · 2022Article
- Tail proteins of phage SU10 reorganize into the nozzle for genome delivery.Nature communications · 2022Article
- Host Range Expansion ofJournal of virology · 2022Article
- Shigella viruses Sf22 and KRT47 require outer membrane protein C for infection.Biochimica et biophysica acta. Biomembranes · 2022Article
- Mosaic Evolution of Beta-Barrel-Porin-Encoding Genes inApplied and environmental microbiology · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Despite being essential for successful infection, the molecular cues involved in host recognition and genome transfer of viruses are not completely understood. Bacterial outer membrane proteins A and C co-purify in lipid vesicles with bacteriophage Sf6, implicating both outer membrane proteins as potential host receptors. We determined that outer membrane proteins A and C mediate Sf6 infection by dramatically increasing its rate and efficiency. We performed a combination of in vivo studies with three omp null mutants of Shigella flexneri, including classic phage plaque assays and time-lapse fluorescence microscopy to monitor genome ejection at the single virion level. Cryo-electron tomography of phage 'infecting' outer membrane vesicles shows the tail needle contacting and indenting the outer membrane. Lastly, in vitro ejection studies reveal that lipopolysaccharide and outer membrane proteins are both required for Sf6 genome release. We conclude that Sf6 phage entry utilizes either outer membrane proteins A or C, with outer membrane protein A being the preferred receptor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.