Trial reportJournal of veterinary internal medicine
Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole treatment in female dogs with uncomplicated bacterial cystitis.
Trial report in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Adverse events of trimetroprim-sulphonamide treatment of cats and dogs: a systematic review.Veterinary research communications · 2026Pooled it
- Short versus longer duration antibiotic treatment for urinary tract infections in companion animals: a systematic review and meta-analysis.BMC veterinary research · 2025Pooled it
- Not just another "AMR is important" message yet again… How veterinarians are making clear progress on better use of antimicrobials.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Antimicrobial Resistance in Companion Animals: A 30-Month Analysis on Clinical Isolates from Urinary Tract Infections in a Veterinary Hospital.Animals : an open access journal from MDPI · 2025Article
- Molecular characterization of uropathogenicJournal of veterinary science · 2025Article
- Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin.Frontiers in veterinary science · 2024Article
- A double-blinded randomized placebo-controlled non-inferiority trial protocol for postoperative infections associated with canine pyometra.BMC veterinary research · 2023Article
- Prevalence and Antimicrobial Resistance of Bacterial Uropathogens Isolated from Dogs and Cats.Antibiotics (Basel, Switzerland) · 2022Article
- In Vitro Killing of Canine Urinary Tract Infection Pathogens by Ampicillin, Cephalexin, Marbofloxacin, Pradofloxacin, and Trimethoprim/Sulfamethoxazole.Microorganisms · 2021Article
- Evaluation of antimicrobial prescriptions in dogs with suspected bacterial urinary tract disease.Journal of veterinary internal medicine · 2021Article
- Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy.Antibiotics (Basel, Switzerland) · 2021Article
- Use of Local Antibiogram Data and Antimicrobial Importance Ratings to Select Optimal Empirical Therapies for Urinary Tract Infections in Dogs and Cats.Antibiotics (Basel, Switzerland) · 2020Article
- Urinary tract infection and subclinical bacteriuria in cats: A clinical update.Journal of feline medicine and surgery · 2019Review
- Optimization of Antimicrobial Treatment to Minimize Resistance Selection.Microbiology spectrum · 2018Review
- Characterization of the urinary microbiome in healthy dogs.PloS one · 2017Article
- Prospective study evaluating the incidence of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing chemotherapy.Veterinary medicine and science · 2016Article
- Urinary tract infections: treatment/comparative therapeutics.The Veterinary clinics of North America. Small animal practice · 2015Review
- Evaluation of the efficacy of a live Escherichia coli biotherapeutic product (asymptomatic bacteriuria E. coli 212).Journal of veterinary internal medicineArticle
- Urethral obstruction and urolithiasis associated with patent urachus in a 12-week-old kitten.JFMS open reportsArticle
- Antimicrobial Susceptibility Patterns in Urinary Tract Infections in Dogs (2010-2013).Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-duration beta-lactam antibiotics are used for empirical treatment in female dogs with uncomplicated bacterial cystitis. However, women with bacterial cystitis are treated with short-duration potentiated sulfonamides because longer courses of beta-lactams result in lower cure and higher recurrence rates. HYPOTHESIS/
objectivesShort-duration potentiated sulfonamide treatment is more efficacious than long-duration beta-lactam treatment in achieving clinical and microbiological cures in female dogs with uncomplicated bacterial cystitis. ANIMALS: Thirty-eight client-owned female dogs.
methodsRandomized, double-blinded, placebo-controlled clinical trial. Dogs were treated with TMP-SMX (15 mg/kg PO q12h for 3 days followed by a placebo capsule PO q12h for 7 days; Group SDS; n = 20) or cephalexin (20 mg/kg PO q12h for 10 days; Group LDBL; n = 18). Dogs were monitored for clinical and microbiological cure during treatment and at short- and long-term follow-up.
resultsNo statistically significant differences were found between treatment groups in clinical cure rates after 3 days of treatment (89% SDS, 94% LDBL; P = 1.00) and 4 days (85% SDS, 72% LDBL; P = .44) or >30 days (50% SDS, 65% LDBL; P = .50) after conclusion of treatment or in microbiological cure rates 4 days (59% SDS, 36% LDBL; P = .44) or >30 days (44% SDS, 20% LDBL; P = .40) after conclusion of treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: We did not identify a difference in cure rates between short-duration sulfonamide and long-duration beta-lactam treatments in female dogs with uncomplicated cystitis. Long-term cure rates in both treatment groups were low. In some female dogs, "uncomplicated" bacterial cystitis may be more complicated than previously recognized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.