ArticleMolecular endocrinology (Baltimore, Md.)2014
Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.
Article in Molecular endocrinology (Baltimore, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Re-analysis of gene mutations found in pituitary stalk interruption syndrome and a new hypothesis on the etiology.Frontiers in endocrinology · 2024Pooled it
- Association Study BetweenInternational journal of molecular sciences · 2026Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Impact of developmental exposures to endocrine-disrupting chemicals on pituitary gland reproductive function.Reproduction (Cambridge, England) · 2024Review
- Pituitary stem cells: past, present and future perspectives.Nature reviews. Endocrinology · 2024Review
- Characterization of Somatotrope Cell Expansion in Response to GHRH in the Neonatal Mouse Pituitary.Endocrinology · 2023Article
- Female-specific pituitary gonadotrope dysregulation in mice with chronic focal epilepsy.Experimental neurology · 2023Article
- Pre- and postnatal developmental exposure to the polychlorinated biphenyl mixture aroclor 1221 alters female rat pituitary gonadotropins and estrogen receptor alpha levels.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- Article
- Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.Endocrinology · 2023Article
- Cellular interactions in the pituitary stem cell niche.Cellular and molecular life sciences : CMLS · 2022Review
- Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.Experimental neurology · 2022Article
- Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty.International journal of molecular sciences · 2022Review
- Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Methylation status of hypothalamicFrontiers in endocrinology · 2022Article
- Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells.Frontiers in endocrinology · 2020Review
- Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?Frontiers in endocrinology · 2020Review
- Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures.Toxicology · 2019Article
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- Article
- Complex integration of intrinsic and peripheral signaling is required for pituitary gland development.Biology of reproduction · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in PROP1 account for up to half of the cases of combined pituitary hormone deficiency that result from known causes. Despite this, few signaling molecules and pathways that influence PROP1 expression have been identified. Notch signaling has been linked to Prop1 expression, but the developmental periods during which Notch signaling influences Prop1 and overall pituitary development remain unclear. To test the requirement for Notch signaling in establishing the normal pituitary hormone milieu, we generated mice with early embryonic conditional loss of Notch2 (conditional knockout) and examined the consequences of chemical Notch inhibition during early postnatal pituitary maturation. We show that loss of Notch2 has little influence on early embryonic pituitary proliferation but is crucial for postnatal progenitor maintenance and proliferation. In addition, we show that Notch signaling is necessary embryonically and postnatally for Prop1 expression and robust Pit1 lineage hormone cell expansion, as well as repression of the corticotrope lineage. Taken together, our studies identify temporal and cell type-specific roles for Notch signaling and highlight the importance of this pathway throughout pituitary development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.