ReviewJournal of neurochemistry2014
Animal models of sports-related head injury: bridging the gap between pre-clinical research and clinical reality.
Review in Journal of neurochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury.Signal transduction and targeted therapy · 2025Article
- Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury.Journal of visualized experiments : JoVE · 2022Article
- Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Repetitive mild traumatic brain injury affects inflammation and excitotoxic mRNA expression at acute and chronic time-points.PloS one · 2021Article
- Chronic traumatic encephalopathy-a blueprint for the bridge between neurological and psychiatric disorders.Translational psychiatry · 2020Review
- Editor's Spotlight/Take 5: Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey.Clinical orthopaedics and related research · 2020Article
- Repetitive, mild traumatic brain injury results in a progressive white matter pathology, cognitive deterioration, and a transient gut microbiota dysbiosis.Scientific reports · 2020Article
- Animal models of closed-skull, repetitive mild traumatic brain injury.Pharmacology & therapeutics · 2019Review
- The neurobiological effects of repetitive head impacts in collision sports.Neurobiology of disease · 2019Review
- Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Protection Before Impact: the Potential Neuroprotective Role of Nutritional Supplementation in Sports-Related Head Trauma.Sports medicine (Auckland, N.Z.) · 2018Review
- Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.Brain : a journal of neurology · 2018Article
- Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons.Experimental brain research · 2017Article
- Repeated Mild Traumatic Brain Injury: Potential Mechanisms of Damage.Cell transplantation · 2017Review
- A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury.Journal of visualized experiments : JoVE · 2017Article
- Animal models of chronic traumatic encephalopathy.Concussion (London, England) · 2017Review
- Article
- Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players.Journal of neurotrauma · 2017Article
- Diffusion imaging of mild traumatic brain injury in the impact accelerated rodent model: A pilot study.Brain injury · 2017Article
- Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.The American journal of pathology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Sports-related head impact and injury has become a very highly contentious public health and medico-legal issue. Near-daily news accounts describe the travails of concussed athletes as they struggle with depression, sleep disorders, mood swings, and cognitive problems. Some of these individuals have developed chronic traumatic encephalopathy, a progressive and debilitating neurodegenerative disorder. Animal models have always been an integral part of the study of traumatic brain injury in humans but, historically, they have concentrated on acute, severe brain injuries. This review will describe a small number of new and emerging animal models of sports-related head injury that have the potential to increase our understanding of how multiple mild head impacts, starting in adolescence, can have serious psychiatric, cognitive and histopathological outcomes much later in life. Sports-related head injury (SRHI) has emerged as a significant public health issue as athletes can develop psychiatric and neurodegenerative disorders later in life. Animal models have always been an integral part of the study of human TBI but few existing methods are valid for studying SRHI. In this review, we propose criteria for effective animal models of SRHI. Movement of the head upon impact is judged to be of primary importance in leading to concussion and persistent CNS dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.