ArticleStem cell reports2014
Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- DisruptedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function.Translational psychiatry · 2021Article
- Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids.Cell and tissue research · 2020Article
- Midbrain Organoids: A New Tool to Investigate Parkinson's Disease.Frontiers in cell and developmental biology · 2020Review
- ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.The Journal of clinical investigation · 2019Article
- Robust Generation of Person-Specific, Synchronously Active Neuronal Networks Using Purely Isogenic Human iPSC-3D Neural Aggregate Cultures.Frontiers in neuroscience · 2019Article
- Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity.Frontiers in molecular neuroscience · 2018Article
- Neuromodulation via the Cerebrospinal Fluid: Insights from RecentFrontiers in neural circuits · 2018Review
- GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks.Frontiers in cellular neuroscience · 2018Article
- Microcircuit formation following transplantation of mouse embryonic stem cell-derived neurons in peripheral nerve.Journal of neurophysiology · 2017Article
- Analysis and Modeling of Subthreshold Neural Multi-Electrode Array Data by Statistical Field Theory.Frontiers in computational neuroscience · 2017Article
- Euchromatin histone methyltransferase 1 regulates cortical neuronal network development.Scientific reports · 2016Article
- Human Cerebrospinal Fluid Promotes Neuronal Viability and Activity of Hippocampal Neuronal Circuits In Vitro.Frontiers in cellular neuroscience · 2016Article
- Stem cell therapy in spinal trauma: Does it have scientific validity?Indian journal of orthopaedicsArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons generated from pluripotent stem cells (PSCs) self-organize into functional neuronal assemblies in vitro, generating synchronous network activities. Intriguingly, PSC-derived neuronal assemblies develop spontaneous activities that are independent of external stimulation, suggesting the presence of thus far undetected intrinsically active neurons (IANs). Here, by using mouse embryonic stem cells, we provide evidence for the existence of IANs in PSC-neuronal networks based on extracellular multielectrode array and intracellular patch-clamp recordings. IANs remain active after pharmacological inhibition of fast synaptic communication and possess intrinsic mechanisms required for autonomous neuronal activity. PSC-derived IANs are functionally integrated in PSC-neuronal populations, contribute to synchronous network bursting, and exhibit pacemaker properties. The intrinsic activity and pacemaker properties of the neuronal subpopulation identified herein may be particularly relevant for interventions involving transplantation of neural tissues. IANs may be a key element in the regulation of the functional activity of grafted as well as preexisting host neuronal networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.