ArticleGut and liver2014
Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study.
Article in Gut and liver, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.Techniques in coloproctology · 2021Pooled it
- The application of defunctioning stomas after low anterior resection of rectal cancer.Surgery today · 2019Pooled it
- 16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial.Scientific data · 2026Trial
- Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer.The British journal of surgery · 2019Trial
- Comparison of the effects of stent-based diversion technique versus prophylactic double-lumen ileostomy on intestinal flora in postoperative patients with rectal cancer.Frontiers in microbiology · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Effect of gut microbiota changes on cytokines IL-10 and IL-17 levels in liver transplantation patients.BMC infectious diseases · 2025Article
- High output stoma after surgery for rectal cancer - a risk factor for low anterior resection syndrome?BMC gastroenterology · 2025Article
- Independent risk factors for diversion colitis: a retrospective case-control study.Revista da Associacao Medica Brasileira (1992) · 2025Article
- A case of ulcerative colitis progression after ileostomy reversal following rectal cancer surgery.Gastroenterology report · 2025Article
- The impact of faecal diversion on the gut microbiome: a systematic review.Gut microbiome (Cambridge, England) · 2024Review
- An updated review on the treatment for diversion colitis and pouchitis, with a focus on the utility of autologous fecal microbiota transplantation and its relationship with the intestinal microbiota.Bioscience of microbiota, food and health · 2024Review
- Low anterior resection syndrome following rectal cancer surgery: are incidence and severity lower with long-term follow-up?Techniques in coloproctology · 2022Article
- Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis.DEN open · 2022Article
- The Gut Microbiota in Liver Transplantation Recipients During the Perioperative Period.Frontiers in physiology · 2022Article
- Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives.Computational and structural biotechnology journal · 2022Review
- Novel application of infliximab for diversion colitis.BMJ case reports · 2021Article
- Article
- Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis.Biochemistry and biophysics reports · 2021Article
- Quality of Life and Bowel Function Following Early Closure of a Temporary Ileostomy in Patients with Rectal Cancer: A Report from a Single-Center Randomized Controlled Trial.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsDiversion colitis is the inflammation of the excluded segment of the colon in patients undergoing ostomy. It has been suggested that a change in colonic flora may lead to colitis; however, direct evidence for this disease progression is lacking. The aim of this study was to evaluate the relationship between the severity of diversion colitis and the composition of colonic bacteria.
methodsWe used culture methods and polymerase chain reaction to analyze the colonic microflora of patients who underwent rectal cancer resection with or without diversion ileostomy. In the diversion group, we also evaluated the severity of colonoscopic and pathologic colitis before reversal.
resultsThis study enrolled 48 patients: 26 in the diversion group and 22 in the control group. Significant differences were observed between the two groups in the levels of Staphylococcus (p=0.038), Enterococcus (p<0.001), Klebsiella (p<0.001), Pseudomonas (p=0.015), Lactobacillus (p=0.038), presence of anaerobes (p=0.019), and Bifidobacterium (p<0.001). A significant correlation between the severity of colitis and bacterial composition was only observed for Bifidobacterium (p=0.005, correlation coefficient=-0.531).
conclusionsThe colonic microflora differed significantly between the diversion and control groups. Bifidobacterium was negatively correlated with the severity of diversion colitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.