ArticleFrontiers in microbiology2014
Insusceptibility to disinfectants in bacteria from animals, food and humans-is there a link to antimicrobial resistance?
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Reviewing the complexities of bacterial biocide susceptibility and in vitro biocide adaptation methodologies.npj antimicrobials and resistance · 2025Review
- Unraveling Antimicrobial Resistance Dynamics in Mycoplasma gallisepticum: Insights Into Antibiotic and Disinfectant Interactions.Veterinary medicine and science · 2025Article
- Influence of antibiotic resistance on disinfectant tolerance of Escherichia coli, Staphylococcus aureus, Enterococcus faecium and Campylobacter jejuni.Access microbiology · 2025Article
- Virulence Factors and Susceptibility to Ciprofloxacin, Vancomycin, Triclosan, and Chlorhexidine among Enterococci from Clinical Specimens, Food, and Wastewater.Microorganisms · 2024Article
- A Clean and Health-Care-Focused Way to Reduce Indoor Airborne Bacteria in Calf House with Long-Wave Ultraviolet.Microorganisms · 2024Article
- Improvements of weaned pigs barn hygiene to reduce the spread of antimicrobial resistance.Frontiers in microbiology · 2024Article
- Current insights into the effects of cationic biocides exposure onFrontiers in microbiology · 2024Review
- UnravelingMicrobiology spectrum · 2023Article
- Review
- Upregulation ofHealth science reports · 2021Article
- Reduced Susceptibility to Biocides among Enterococci from Clinical and Non-Clinical Sources.Infection & chemotherapy · 2021Article
- Directed Recovery and Molecular Characterization of Antibiotic Resistance Plasmids from Cheese Bacteria.International journal of molecular sciences · 2021Article
- Biocide Use in the Antimicrobial Era: A Review.Molecules (Basel, Switzerland) · 2021Review
- Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance inMicroorganisms · 2021Article
- Evaluation of a Newly Developed Vacuum Dried Microtiter Plate for Rapid Biocide Susceptibility Testing of ClinicalMicroorganisms · 2020Article
- Antimicrobial Peptide-Polymer Conjugates for Dentistry.ACS applied polymer materials · 2020Article
- Accumulation of antibiotic-resistant genes in anaerobic biofilm reactor fed with household chemical products.SN applied sciences · 2020Article
- Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Review
- De-repression of theAntimicrobial agents and chemotherapy · 2019Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococcus faecalis (n = 834) and Enterococcus faecium (n = 135) from blood and feces of hospitalized humans, from feces of outpatients and livestock and from food were screened for their susceptibility to a quaternary ammonium compound (didecyldimethylammoniumchloride, DDAC) and to 28 antibiotics by micro-/macrodilution. The maximum DDAC-MIC in our field study was 3.5 mg/l, but after adaptation in the laboratory, MIC values of 21.9 mg/l were observed. Strains for which DDAC had MICs > 1.4 mg/l ("non-wildtype," in total: 46 of 969 isolates/4.7%) were most often found in milk and dairy products (14.6%), while their prevalence in livestock was generally low (0-4%). Of human isolates, 2.9-6.8% had a "non-wildtype" phenotype. An association between reduced susceptibility to DDAC, high-level-aminoglycoside resistance and aminopenicillin resistance was seen in E. faecium (p < 0.05). No indications for a common source of non-wildtype strains were found by RAPD-PCR; however, several non-wildtype E. faecalis shared the same variant of the emeA-gene. In addition, bacteria (n = 42) of different genera were isolated from formic acid based boot bath disinfectant (20 ml of 55% formic acid/l). The MICs of this disinfectant exceeded the wildtype MICs up to 20-fold (staphylococci), but were still one to three orders of magnitude below the used concentration of the disinfectant (i. e., 1.1% formic acid). In conclusion, the bacterial susceptibility to disinfectants still seems to be high. Thus, the proper use of disinfectants in livestock surroundings along with a good hygiene praxis should still be highly encouraged. Hints to a link between antibiotic resistance and reduced susceptibility for disinfectants-as seen for E. faecium-should be substantiated in further studies and might be an additional reason to confine the use of antibiotics.
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