ArticleFrontiers in microbiology2014
Reduced disease in black abalone following mass mortality: phage therapy and natural selection.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Limited genomic signatures of population collapse in the critically endangered black abalone (Haliotis cracherodii).Molecular ecology · 2025Article
- Sea star wasting disease mystery finally solved.Nature ecology & evolution · 2025Article
- Bacteriophage Therapy in Freshwater and Saltwater Aquaculture Species.Microorganisms · 2025Review
- High infectivity and waterborne transmission of seagrass wasting disease.Royal Society open science · 2024Article
- Limited genomic signatures of population collapse in the critically endangered black abalone (bioRxiv : the preprint server for biology · 2024Article
- Microbial threats and sustainable solutions for molluscan aquaculture.Sustainable microbiology · 2024Review
- Partitioning variance in immune traits in a zooplankton host-Fungal parasite system.Ecology and evolution · 2022Article
- Strategies for managing marine disease.Ecological applications : a publication of the Ecological Society of America · 2022Article
- Differential Mortality and High Viral Load in Naive Pacific Oyster Families Exposed to OsHV-1 Suggests Tolerance Rather than Resistance to Infection.Pathogens (Basel, Switzerland) · 2020Article
- Differing responses of red abalone (PeerJ · 2018Article
- Managing marine disease emergencies in an era of rapid change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Complementary approaches to diagnosing marine diseases: a union of the modern and the classic.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Does influenza A virus infection affect movement behaviour during stopover in its wild reservoir host?Royal Society open science · 2016Article
- Editorial: Roles and mechanisms of parasitism in aquatic microbial communities.Frontiers in microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black abalone, Haliotis cracherodii, populations along the NE Pacific ocean have declined due to the rickettsial disease withering syndrome (WS). Natural recovery on San Nicolas Island (SNI) of Southern California suggested the development of resistance in island populations. Experimental challenges in one treatment demonstrated that progeny of disease-selected black abalone from SNI survived better than did those from naïve black abalone from Carmel Point in mainland coastal central California. Unexpectedly, the presence of a newly observed bacteriophage infecting the WS rickettsia (WS-RLO) had strong effects on the survival of infected abalone. Specifically, presence of phage-infected RLO (RLOv) reduced the host response to infection, RLO infection loads, and associated mortality. These data suggest that the black abalone: WS-RLO relationship is evolving through dual host mechanisms of resistance to RLO infection in the digestive gland via tolerance to infection in the primary target tissue (the post-esophagus) coupled with reduced pathogenicity of the WS-RLO by phage infection, which effectively reduces the infection load in the primary target tissue by half. Sea surface temperature patterns off southern California, associated with a recent hiatus in global-scale ocean warming, do not appear to be a sufficient explanation for survival patterns in SNI black abalone. These data highlight the potential for natural recovery of abalone populations over time and that further understanding of mechanisms governing host-parasite relationships will better enable us to manage declining populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.