ArticleFrontiers in neuroanatomy2014
Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02852213 (SIngle-Stage, Open-Label, Safety and Efficacy Study of Adeno-Associated Virus Encoding Human Aromatic L-Amino Acid Decarboxylase by Magnetic Resonance MR-guided Infusion Into Midbrain in Pediatric Patients With AADC Deficiency), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SIngle-Stage, Open-Label, Safety and Efficacy Study of Adeno-Associated Virus Encoding Human Aromatic L-Amino Acid Decarboxylase by Magnetic Resonance MR-guided Infusion Into Midbrain in Pediatric Patients With AADC Deficiency
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
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- Unilateral Administration of Surface-Modified G1 and G4 PAMAM Dendrimers in Healthy Mice to Assess Dendrimer Migration in the Brain.ACS applied materials & interfaces · 2024Article
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- PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain.Theranostics · 2023Article
- 1,2-Dimyristoyl-RSC advances · 2021Article
- Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke.Science advances · 2021Article
- The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease.BioMed research international · 2021Review
- MRI of Whole Rat Brain Perivascular Network Reveals Role for Ventricles in Brain Waste Clearance.Scientific reports · 2019Article
- The synthesis and characterization of glutathione-modified superparamagnetic iron oxide nanoparticles and their distribution in rat brains after injection in substantia nigra.Journal of materials science. Materials in medicine · 2018Article
- Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches.Bioconjugate chemistry · 2018Review
- Strategies to enhance the distribution of nanotherapeutics in the brain.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.Journal of neurosurgery · 2017Review
- Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging.Stem cells translational medicine · 2017Article
- Optogenetic manipulation of neural circuits in awake marmosets.Journal of neurophysiology · 2016Article
- Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates.Human gene therapy methods · 2016Article
- Delivery of the 7-dehydrocholesterol reductase gene to the central nervous system using adeno-associated virus vector in a mouse model of Smith-Lemli-Opitz Syndrome.Molecular genetics and metabolism reports · 2015Article
- Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain.Advanced healthcare materials · 2015Article
- Neuroanatomy and transgenic technologies.Frontiers in neuroanatomy · 2014Article
- Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
When nanoparticles/proteins are infused into the brain, they are often transported to distal sites in a manner that is dependent both on the characteristics of the infusate and the region targeted. We have previously shown that adeno-associated virus (AAV) is disseminated within the brain by perivascular flow and also by axonal transport. Perivascular distribution usually does not depend strongly on the nature of the infusate. Many proteins, neutral liposomes and AAV particles distribute equally well by this route when infused under pressure into various parenchymal locations. In contrast, axonal transport requires receptor-mediated uptake of AAV by neurons and engagement with specific transport mechanisms previously demonstrated for other neurotropic viruses. Cerebrospinal fluid (CSF) represents yet another way in which brain anatomy may be exploited to distribute nanoparticles broadly in the central nervous system. In this study, we assessed the distribution and perivascular transport of nanoparticles of different sizes delivered into the parenchyma of rodents and CSF in non-human primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.