ArticleTheScientificWorldJournal2014
Anthelmintic activity of crude extract and essential oil of Tanacetum vulgare (Asteraceae) against adult worms of Schistosoma mansoni.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026Review
- Anthelmintic Activity ofAnimals : an open access journal from MDPI · 2023Article
- An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023Review
- Essential Oils as Novel Anthelmintic Drug Candidates.Molecules (Basel, Switzerland) · 2022Review
- Antischistosomal effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Ethnomedicinal and Ethnobotanical Survey in the Aosta Valley Side of the Gran Paradiso National Park (Western Alps, Italy).Plants (Basel, Switzerland) · 2022Article
- The Activity of Plant Crude Extracts againstJournal of parasitology research · 2021Review
- Antiparasitic effects of ethanolic extracts ofParasitology · 2020Article
- In vitro Effects ofResearch and reports in tropical medicine · 2020Article
- The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis.BMC complementary and alternative medicine · 2016Article
- ULTRASTRUCTURAL CHANGES IN Schistosoma mansoni MALE WORMS AFTER in vitro INCUBATION WITH THE ESSENTIAL OIL OF Mentha x villosa Huds.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Flavonoids and Sesquiterpene Lactones fromEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.PLoS neglected tropical diseases · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Tanacetum vulgare (Asteraceae) is used in folk medicine as a vermifuge. This study aimed to investigate the in vitro schistosomicidal activity of the crude extract (TV) and the essential oil (TV-EO) from the aerial parts of T. vulgare. TV-EO was obtained by hydrodistillation and analyzed by GC/MS, which allowed the identification of β-thujone (84.13%) as the major constituent. TV and TV-EO, at 200 μg/mL, decreased motor activity and caused 100% mortality of all adult worms. At 100 and 50 μg/mL, only TV caused death of all adult worms, while TV-EO was inactive. TV (200 μg/mL) was also able to reduce viability and decrease production of developed eggs. Confocal laser scanning microscopy showed morphological alterations in the tegument of the S. mansoni surface after incubation with TV (50 and 100 μg/mL). Quantitative analysis on the schistosomes tegument showed that TV caused changes in the numbers of tubercles of S. mansoni male worms in a dose-dependent manner. The findings suggest that T. vulgare is a potential source of schistosomicidal compounds.
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