ArticleTherapeutics and clinical risk management2014
Medication transitions and polypharmacy in older adults following acute care.
Article in Therapeutics and clinical risk management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Prevalence and factors associated with polypharmacy: a systematic review and Meta-analysis.BMC geriatrics · 2022Pooled it
- A randomised trial of pharmacist-led discharge prescribing in an Australian geriatric evaluation and management service.International journal of clinical pharmacy · 2021Trial
- Medication Discrepancies among Older Hospitalized Adults Discharged from Post-Acute Care Facilities to Home.Journal of the American Medical Directors Association · 2024Article
- Challenges in Deprescribing among Older Adults in Post-Acute Care Transitions to Home.Journal of the American Medical Directors Association · 2024Article
- How to Deprescribe Potentially Inappropriate Medications During the Hospital-to-Home Transition: Stakeholder Perspectives on Essential Tasks.Clinical therapeutics · 2023Article
- The role of INTERCheckWEB digital innovation in supporting polytherapy management.Scientific reports · 2023Article
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Polypharmacy and potentially inappropriate medications in stroke rehabilitation: prevalence and association with outcomes.International journal of clinical pharmacy · 2022Article
- Older Patient and Surrogate Attitudes Toward Deprescribing During the Transition From Acute to Post-Acute Care.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- Association of polypharmacy at hospital discharge with nutritional intake, muscle strength, and activities of daily living among older patients undergoing convalescent rehabilitation after stroke.Japanese journal of comprehensive rehabilitation science · 2022Article
- Pharmacotherapy and the Role of Pharmacists in Rehabilitation Medicine.Progress in rehabilitation medicine · 2022Review
- Investigation of drug-related problems in patients hospitalized in chest disease wards: A randomized controlled trial.Frontiers in pharmacology · 2022Article
- Potentially inappropriate medications and medication combinations before, during and after hospitalizations: an analysis of pathways and determinants in the Swiss healthcare setting.BMC health services research · 2021Article
- Impact of emergency hospital admissions on patterns of primary care prescribing: a retrospective cohort analysis of electronic records in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- Community-acquired pneumonia in critically ill very old patients: a growing problem.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?BMC pharmacology & toxicology · 2019Article
- A patient-centered deprescribing intervention for hospitalized older patients with polypharmacy: rationale and design of the Shed-MEDS randomized controlled trial.BMC health services research · 2019Article
- Shed-MEDS: pilot of a patient-centered deprescribing framework reduces medications in hospitalized older adults being transferred to inpatient postacute care.Therapeutic advances in drug safety · 2018Article
- Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia.Frontiers in immunology · 2018Review
- Prevalence and Covariates of Polypharmacy in Elderly Patients on Discharge from a Tertiary Care Hospital in Oman.Oman medical journal · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveMedication changes at transitions of care and polypharmacy are growing concerns that adversely impact optimal drug use. We aimed to describe transitions and patterns of medication use before and 1 year after older patients were hospitalized for community-acquired pneumonia, the second-most common reason for admission in North America. MATERIALS AND
methodsThis was an analysis of a population-based clinical registry of patients treated in any of the six hospitals or seven emergency departments in Edmonton, Alberta, Canada, comprising 2,105 patients 65 years and older with community-acquired pneumonia who had survived at least 1 year. The prevalence of polypharmacy (five or more unique prescription drugs), as well as new use and persistence of common drug classes were assessed.
resultsThe mean age was 78 years (standard deviation 8 years), 50% were female, 62% were hospitalized, and 58% had severe pneumonia. Among the 2,105 patients, 949 (45%) were using five or more medications prior to hospitalization, increasing to 1,559 (74%) within 90 days postdischarge and remaining over 70% at 1 year. Overall, 1,690 (80%) patients newly started and 1,553 (74%) patients stopped at least one medication in the first 90 days of follow-up. The prevalence of the most common drug classes (ie, cardiovascular, alimentary/metabolism) remained stable, with the exception of anti-infective agents, whereby 25% of patients were dispensed an anti-infective agent 3 months to 1 year after hospitalization.
conclusionMost older patients with pneumonia are subject to polypharmacy, and almost every patient had a medication started or stopped during 1-year follow-up, with 25% using antibiotics again. The period following an episode of pneumonia represents an opportunity potentially to optimize pharmacotherapy.
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