Evidence map›Paper›PMID 24672232›Full record

Trial reportClinical interventions in aging2014

Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.

Vilai Kuptniratsaikul, Piyapat Dajpratham, Wirat Taechaarpornkul, Montana Buntragulpoontawee, Pranee Lukkanapichonchut, Chirawan Chootip, Jittima Saengsuwan, Kesthamrong Tantayakom, Supphalak Laongpech

2 registry-linked trialsOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical interventions in aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 16 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03175757 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized, Single-blind, Placebo-controlled Study to Evaluate the Effects of a Turmeric and Black Cumin Seed Formulation on Cholesterol Levels Among Generally Healthy Participants

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2017 to 2018Enrolled33ConditionsCholesterol HealthArmsTurmeric and Black Cumin Seed, Placebo
NCT06359665 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis

TypeinterventionalSponsorBrent DeGeorgeRan2025 to 2026Enrolled100ConditionsArthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right ThumbArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 16 syntheses or guidelines pooled it, 299 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The Search for Drugs Derived from Natural Products forCurrent topics in medicinal chemistry · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Efficacy and Safety of Curcumin andFrontiers in immunology · 2022
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Guideline
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Trial
  19. Trial
  20. Trial

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Vilai KuptniratsaikulDepartment of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Piyapat DajprathamDepartment of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Wirat TaechaarpornkulSirindhorn National Medical Rehabilitation Center, Ministry of Public Health, Nonthaburi, Thailand.
Montana BuntragulpoontaweeDepartment of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pranee LukkanapichonchutDepartment of Rehabilitation Medicine, Ratchaburi Hospital, Ministry of Public Health, Ratchaburi, Thailand.
Chirawan ChootipDepartment of Rehabilitation Medicine, Songkhla Hospital, Ministry of Public Health, Songkhla, Thailand.
Jittima SaengsuwanDepartment of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Kesthamrong TantayakomDepartment of Rehabilitation Medicine, Rajvithi Hospital, Ministry of Public Health, Bangkok, Thailand.
Supphalak LaongpechDepartment of Rehabilitation Medicine, Vachira Phuket Hospital, Ministry of Public Health, Phuket, Thailand.
Siriraj Hospital · THChiang Mai University · THKhon Kaen University · THRatchaburi Hospital · THVachira Phuket Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the efficacy and safety of Curcuma domestica extracts in pain reduction and functional improvement.

methods367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day or C. domestica extracts 1,500 mg/day for 4 weeks. The main outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total, WOMAC pain, WOMAC stiffness, and WOMAC function scores. Adverse events (AEs) were also recorded.

results185 and 182 patients were randomly assigned into C. domestica extracts and ibuprofen groups, respectively. The baseline characteristics were no different between groups. The mean of all WOMAC scores at weeks 0, 2, and 4 showed significant improvement when compared with the baseline in both groups. After using the noninferiority test, the mean difference (95% confidence interval) of WOMAC total, WOMAC pain, and WOMAC function scores at week 4 adjusted by values at week 0 of C. domestica extracts were noninferior to those for the ibuprofen group (P=0.010, P=0.018, and P=0.010, respectively), except for the WOMAC stiffness subscale, which showed a trend toward significance (P=0.060). The number of patients who developed AEs was no different between groups. However, the number of events of abdominal pain/discomfort was significantly higher in the ibuprofen group than that in the C. domestica extracts group (P=0.046). Most subjects (96%-97%) were satisfied with the treatment, and two-thirds rated themselves as improved in a global assessment.

conclusionC. domestica extracts are as effective as ibuprofen for the treatment of knee osteoarthritis. The side effect profile was similar but with fewer gastrointestinal AE reports in the C. domestica extracts group.

Indexed as

CurcumaAnti-Inflammatory Agents, Non-SteroidalFemaleHumansIbuprofenMaleMiddle AgedOsteoarthritis, KneePhytotherapyPlant ExtractsTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalIbuprofenPlant ExtractsCurcuma domesticacurcuminefficacyibuprofenknee osteoarthritissafety

Identifiers

PMID24672232
PMCPMC3964021
OpenAlexW2086170145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.