ReviewClinical ophthalmology (Auckland, N.Z.)2014
Diagnosis of dry eye disease and emerging technologies.
Review in Clinical ophthalmology (Auckland, N.Z.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.
- Advances in Dry Eye Disease Examination Techniques.Frontiers in medicine · 2021Pooled it
- Efficacy and Safety of Artificial Tears Containing Lipidure and Hypromellose for the Treatment of Moderate Dry Eye Disease in Contact Lens Wearers.Medicina (Kaunas, Lithuania) · 2024Trial
- Dry Eye Subtypes in the Dry Eye Assessment and Management (DREAM) Study: A Latent Profile Analysis.Translational vision science & technology · 2022Trial
- Trial
- Upper airway stabilization by osteopathic manipulation of the sphenopalatine ganglion versus sham manipulation in OSAS patients: a proof-of-concept, randomized, crossover, double-blind, controlled study.BMC complementary and alternative medicine · 2017Trial
- Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome.Advances in therapy · 2015Trial
- Dry eye detection based on multidimensional temporal features of fluorescein tear film videos.Quantitative imaging in medicine and surgery · 2026Article
- Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin.Life (Basel, Switzerland) · 2026Review
- Recent advances in smart contact lenses.Biosensors & bioelectronics: X · 2026Article
- Bench-to-Bedside Perspectives on Ocular Toxicity of Antibody-Drug Conjugates: Toxicology, Clinical Management and Molecule Optimization.Pharmaceutical research · 2026Review
- Dry Eye Disease And The Jenvis Dry Eye Report Diagnosis Tool: A Literature Review with Emphasis On African Populations.Clinical optometry · 2026Review
- Potential ocular health benefit of short-term omega-3 fatty acids supplementation on the ocular tear film: An observational study.Medicine · 2025Observational
- A Comprehensive Review Comparing Artificial Intelligence and Clinical Diagnostic Approaches for Dry Eye Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Lissamine Green in Ophthalmology: A Comprehensive Review of Diagnostic and Clinical Applications.Ophthalmology and therapy · 2025Review
- Overview of Dry Eye Disease for Primary Care Physicians.Medicina (Kaunas, Lithuania) · 2025Review
- Efficacy of a new nanoemulsion artificial tear in dry eye disease management: Study protocol for a prospective cohort study.PloS one · 2025Article
- Efficacy of 0.05% Cyclosporine-A eye drops (II) and 3% Diquafosol ophthalmic solution in the treatment of dry eye after cataract surgery.Pakistan journal of medical sciences · 2024Article
- Classifying Dry Eye Disease Patients from Healthy Controls Using Machine Learning and Metabolomics Data.Diagnostics (Basel, Switzerland) · 2024Article
- Potential applications of artificial intelligence in image analysis in cornea diseases: a review.Eye and vision (London, England) · 2024Review
- Validation of the phenol red thread test in a Chinese population.BMC ophthalmology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dry eye is one of the most commonly encountered problems in ophthalmology. Signs can include punctate epithelial erosions, hyperemia, low tear lakes, rapid tear break-up time, and meibomian gland disease. Current methods of diagnosis include a slit-lamp examination with and without different stains, including fluorescein, rose bengal, and lissamine green. Other methods are the Schirmer test, tear function index, tear break-up time, and functional visual acuity. Emerging technologies include meniscometry, optical coherence tomography, tear film stability analysis, interferometry, tear osmolarity, the tear film normalization test, ocular surface thermography, and tear biomarkers. Patient-specific considerations involve relevant history of autoimmune disease, refractive surgery or use of oral medications, and allergies or rosacea. Other patient considerations include clinical examination for lid margin disease and presence of lagophthalmos or blink abnormalities. Given a complex presentation and a variety of signs and symptoms, it would be beneficial if there was an inexpensive, readily available, and reproducible diagnostic test for dry eye.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.