ReviewClinical ophthalmology (Auckland, N.Z.)2014
Diagnosis and management of neurotrophic keratitis.
Review in Clinical ophthalmology (Auckland, N.Z.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 176 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells for Promoting Corneal Repair
Structural and Functional Changes of Corneal Innervation After Treatment With Cenegermin
Efficacy of Locally Delivered Allogeneic Mesenchymal Stem Cells for Promoting Corneal Repair
Who cites it
176 citing papers in PubMed, 354 citations in OpenAlex.
- Characteristics of the ocular surface in neurotrophic keratitis induced by trigeminal nerve injury following neurosurgery.International ophthalmology · 2023Trial
- 0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial.International journal of molecular sciences · 2022Trial
- Review
- Neurotrophic effects of topical insulin in persistent epithelial defects.International ophthalmology · 2026Article
- Topical Insulin for Corneal Persistent Epithelial Defects: A Multicenter Retrospective Study.Ophthalmology and therapy · 2026Article
- Surgical interventions in herpes simplex virus keratitis: Outcomes in a large cohort.Indian journal of ophthalmology · 2026Observational
- Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry.Arthritis care & research · 2026Article
- In vivo confocal microscopy findings from full corneal epithelial debridement and local corticosteroid for recurrent corneal erosion.Eye (London, England) · 2026Article
- The Role of Innervation in Ocular Surface Homeostasis, Tissue Remodeling Following Nerve Injury, and the Therapeutic Potential of Hemocomponents in Neuronal and Cicatricial Pathologies.Journal of clinical medicine · 2026Review
- Comparison of Effectiveness of Biovance Single and Triple Layer Decellularized Basement Membranes for Treatment of Ocular Surface Disease: A Retrospective Study.Clinical optometry · 2026Article
- Management of Stage 1 Neurotrophic Keratopathy with Shelf-Stable, Cryopreserved Amniotic Membrane: A Retrospective Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Corneal Sensitivity with the Non-contact Esthesiometer as Compared to the Cotton Wisp Test in Patients with Ocular Surface Diseases.Ophthalmology and therapy · 2026Article
- Defining Criteria for Choosing Corneal Neurotization in Neurotrophic Keratopathy: A Systematic Review Along with Practical Advices.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- The Therapeutic Approach and Mechanism of Action of Insulin Eye Drops for the Treatment of Neurotrophic Keratitis.Drug design, development and therapy · 2026Review
- Machine Learning Identifies Predictors of Amniotic Membrane Graft Failure in Neurotrophic Keratitis.Ophthalmology and therapy · 2025Article
- Cenegermin for the Treatment of Moderate or Severe Neurotrophic Keratopathy: Results from a Prospective, Phase IV, Open-Label Study in China.Ophthalmology and therapy · 2025Article
- In vivo confocal microscopy (IVCM) analysis of corneal sub-basal nerve plexus (SNP) and corneal sensitivity after micropulse transscleral cyclophotocoagulation (MP-TSCPC) in glaucoma patients.International ophthalmology · 2025Article
- Polyneuritis cranialis following actinomycosis of a wisdom tooth: a case report.Journal of medical case reports · 2025Article
- Article
- The eye as a window to oral and pain symptoms in Sjögren's disease.The British journal of ophthalmology · 2025Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophic keratitis (NK) is a degenerative disease characterized by corneal sensitivity reduction, spontaneous epithelium breakdown, and impairment of corneal healing. Several causes of NK, including herpetic keratitis, diabetes, and ophthalmic and neurosurgical procedures, share the common mechanism of trigeminal damage. Diagnosis of NK requires accurate investigation of clinical ocular and systemic history, complete eye examination, and assessment of corneal sensitivity. All diagnostic procedures to achieve correct diagnosis and classification of NK, including additional examinations such as in vivo confocal microscopy, are reviewed. NK can be classified according to severity of corneal damage, ie, epithelial alterations (stage 1), persistent epithelial defect (stage 2), and corneal ulcer (stage 3). Management of NK should be based on clinical severity, and aimed at promoting corneal healing and preventing progression of the disease to stromal melting and perforation. Concomitant ocular diseases, such as exposure keratitis, dry eye, and limbal stem cell deficiency, negatively influence the outcome of NK and should be treated. Currently, no specific medical treatment exists, and surgical approaches, such as amniotic membrane transplantation and conjunctival flap, are effective in preserving eye integrity, without ameliorating corneal sensitivity or visual function. This review describes experimental and clinical reports showing several novel and potential therapies for NK, including growth factors and metalloprotease inhibitors, as well as three ongoing Phase II clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.