ReviewJournal of mid-life health2014
Obesity: Friend or foe for osteoporosis.
Review in Journal of mid-life health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity.Obesity (Silver Spring, Md.) · 2019Trial
- Dietary Vitamin D Supplementation Improves Hair Follicle Development and Affects Fatty Acid Metabolism in Rex Rabbits.Food science & nutrition · 2025Article
- Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis.International journal of molecular sciences · 2023Article
- Risk Factors of Osteoporosis in Females: A Hospital-Based Case-Control Study, Yazd, Iran.Iranian journal of public health · 2022Article
- Associations Between Body Mass Index, WNT16 rs2908004 and Osteoporosis: Findings from Taiwan Biobank.Journal of multidisciplinary healthcare · 2022Article
- The Relationship Between Bone Mineral Density and Body Composition Among Qatari Women With High Rate of Obesity: Qatar Biobank Data.Frontiers in nutrition · 2022Article
- Weight Change Is Associated with Osteoporosis: A Cross Sectional Study Using the Korean Community Health Survey.International journal of environmental research and public health · 2021Article
- Association between Metabolic Syndrome and Osteoporosis: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2021Review
- Bone Mineral Density of Femur and Lumbar and the Relation between Fat Mass and Lean Mass of Adolescents: Based on Korea National Health and Nutrition Examination Survey (KNHNES) from 2008 to 2011.International journal of environmental research and public health · 2020Article
- Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update.Clinical interventions in aging · 2020Review
- Effect of Qing'e Decoction on Leptin/Leptin Receptor and Bone Metabolism in Naturally Aging Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women.Archives of endocrinology and metabolism · 2018Article
- Lycium barbarum polysaccharide arbitrates palmitate-induced apoptosis in MC3T3‑E1 cells through decreasing the activation of ERS‑mediated apoptosis pathway.Molecular medicine reports · 2018Article
- Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption.Frontiers in cell and developmental biology · 2018Article
- Association between Anthropometric Indices, Body Composition and Bone Parameters in Thai Female Adolescents.Indian journal of pediatrics · 2017Article
- Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era.International journal of environmental research and public health · 2017Review
- Relationship between serum adiponectin and bone mineral density in male patients with obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2017Article
- Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study.Immunity & ageing : I & A · 2017Article
- Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a.Scientific reports · 2016Article
- Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis and obesity are worldwide health problems. Interestingly, both are associated with significant morbidity and mortality. Both the diseases have common linkage as bone marrow mesenchymal stromal cells are the common precursors for both osteoblasts and adipocytes. Aging may shift composition of bone marrow by increasing adipocytes, osteoclast activity, and decreasing osteoblast activity, resulting into osteoporosis. Adipocytes secret leptin, adiponectin, adipsin, as well as proinflammatory cytokines, that contributes in pathogenesis of osteoporosis. This new concept supports the hypothesis, that the positive correlation of weight and body mass index (BMI) with bone mineral density (BMD) is not confirmed by large population-based studies. Thus, the previous concept, that obesity is protective for osteoporosis may not stand same as bone marrow fat deposition (adipogenesis) seen in obesity, is detrimental for bone health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.