ArticleMediators of inflammation2014
Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Brain natriuretic peptide as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.BMC anesthesiology · 2024Pooled it
- Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Prognostic value of procalcitonin in respiratory tract infections across clinical settings.Critical care (London, England) · 2015Pooled it
- Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock.Diseases (Basel, Switzerland) · 2024Article
- Predicting Mortality in Sepsis: The Role of Dynamic Biomarker Changes and Clinical Scores-A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs.Infection & chemotherapy · 2022Review
- Biomarkers Predicting Tissue Pharmacokinetics of Antimicrobials in Sepsis: A Review.Clinical pharmacokinetics · 2022Review
- [Which biomarkers for diagnosis and guidance of anti-infection treatment in sepsis?]Der Anaesthesist · 2022Review
- The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis.Diagnostics (Basel, Switzerland) · 2021Article
- Predictive value and regulatory mechanism of serum miR-499a-5p on myocardial dysfunction in sepsis.Journal of cardiothoracic surgery · 2021Article
- Point-of-critical-care diagnostics for sepsis enabled by multiplexed micro and nanosensing technologies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Role of Procalcitonin in the Prognosis of Mortality in Patients Admitted to the Intensive Care Unit: A Review Study.Tanaffos · 2021Review
- Evaluation of sTREM1 and suPAR Biomarkers as Diagnostic and Prognostic Predictors in Sepsis Patients.Infection and drug resistance · 2021Article
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- Natriuretic Peptides to Predict Short-Term Mortality in Patients With Sepsis: A Systematic Review and Meta-analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2020Review
- Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children.Mediators of inflammation · 2020Article
- The ability of an improved qSOFA score to predict acute sepsis severity and prognosis among adult patients.Medicine · 2020Observational
- Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis.Annals of intensive care · 2019Article
- Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock.Archivum immunologiae et therapiae experimentalis · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), N-terminal probrain natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), cytokines, and clinical severity scores in patients with sepsis.
methodsA total of 102 patients with sepsis were divided into survival group (n = 60) and nonsurvival group (n = 42) based on 28-day mortality. Serum levels of biomarkers and cytokines were measured on days 1, 3, and 5 after admission to an ICU, meanwhile the acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) scores were calculated.
resultsSerum sTREM-1, PCT, and IL-6 levels of patients in the nonsurvival group were significantly higher than those in the survival group on day 1 (P < 0.01). The area under a ROC curve for the prediction of 28 day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHE II score. Multivariate logistic analysis showed that serum baseline sTREM-1 PCT levels and SOFA score were the independent predictors of 28-day mortality. Serum PCT, sTREM-1, and IL-6 levels showed a decrease trend over time in the survival group (P < 0.05). Serum NT-pro-BNP levels showed the predictive utility from days 3 and 5 (P < 0.05).
conclusionIn summary, elevated serum sTREM-1 and PCT levels provide superior prognostic accuracy to other biomarkers. Combination of serum sTREM-1 and PCT levels and SOFA score can offer the best powerful prognostic utility for sepsis mortality.
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