Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Cue-induced craving increases impulsivity via changes in striatal value signals in problem gamblers.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Craving in gambling disorder: A systematic review.Journal of behavioral addictions · 2023Pooled it
- Cue-reactivity in behavioral addictions: A meta-analysis and methodological considerations.Journal of behavioral addictions · 2018Pooled it
- How We Lost 90% of Participants on a Bad Bet: Results from a Pilot Randomized Controlled Trial on Cognitive Bias Modification in Problem Gamblers.Journal of gambling studies · 2024Trial
- Inhibitory control deficits in problematic short-form video users: evidence from drift diffusion model.BMC psychology · 2026Article
- When cues take the wheel: cue-control across alcohol use disorder, binge-eating disorder, gambling disorder, and internet gaming disorder.Frontiers in psychology · 2026Review
- Addiction spectrum disorder: a conceptual framework for comprehensive understanding of addictive disorders.Frontiers in psychology · 2026Article
- Behavioral and computational signatures of reinforcement learning and confidence biases in gambling disorder.Journal of behavioral addictions · 2025Article
- Decomposition of Reinforcement Learning Deficits in Disordered Gambling via Drift Diffusion Modeling and Functional Magnetic Resonance Imaging.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Reliability and validity of behavioral-economic measures: A review and synthesis of discounting and demand.Journal of the experimental analysis of behavior · 2023Review
- Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder.Journal of behavioral addictions · 2023Article
- Cooling Off and the Effects of Mandatory Breaks in Online Gambling: A Large-Scale Real-World Study.International journal of mental health and addiction · 2023Article
- Erotic cue exposure increases neural reward responses without modulating temporal discounting.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Gambling Environment Exposure Increases Temporal Discounting but Improves Model-Based Control in Regular Slot-Machine Gamblers.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Rewards that are near increase impulsive action.iScience · 2021Article
- Reliability assessment of temporal discounting measures in virtual reality environments.Scientific reports · 2021Article
- Attenuated Directed Exploration during Reinforcement Learning in Gambling Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Event-related potentials in a two-choice oddball task of impaired behavioral inhibitory control among males with tendencies towards cybersex addiction.Journal of behavioral addictions · 2020Article
- A computational model of the Cambridge gambling task with applications to substance use disorders.Drug and alcohol dependence · 2020Article
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impulsive behavior such as steep temporal discounting is a hallmark of addiction and is associated with relapse. In pathological gamblers, discounting may be further increased by the presence of gambling-related cues in the environment, but the extent to which the gambling relatedness of task settings affects reward responses in gambling addiction is debated. In the present study, human problem gamblers made choices between immediate rewards and individually tailored larger-but-later rewards while visual gambling-related scenes were presented in the background. N = 17 participants were scanned using fMRI, whereas N = 5 additional participants completed a behavioral version of the task. Postscan craving ratings were acquired for each image, and behavioral and neuroimaging data were analyzed separately for high- and low-craving trials (median split analysis). Discounting was steeper for high versus low craving trials. Neuroimaging revealed a positive correlation with model-based subjective value in midbrain and striatum in low-craving trials that was reversed in high-craving trials. These findings reveal a modulation of striatal reward responses in gamblers by addiction-related cues, and highlight a potentially important mechanism that may contribute to relapse. Cue-induced changes in striatal delayed reward signals may lead to increased discounting of future rewards, which might in turn affect the likelihood of relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.