ReviewThe Journal of experimental biology2014
No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates.
Review in The Journal of experimental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.
- Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?Neuroscience bulletin · 2025Pooled it
- Age-dependent changes in lipid droplet distribution and vascularization in naked mole rat vs. mouse hippocampus.GeroScience · 2026Article
- Frogs Uncouple Neural Activity From Oxygen Consumption After Hibernation.Acta physiologica (Oxford, England) · 2026Article
- Brain-derived ketone bodies can replace glucose to power neural function.bioRxiv : the preprint server for biology · 2026Article
- Frogs uncouple neural activity from oxygen consumption after hibernation.bioRxiv : the preprint server for biology · 2026Article
- Hypoxia tolerance of intertidal triplefin fish is associated with low critical oxygen tension and high phosphorylating capacity in brain mitochondria.Scientific reports · 2026Article
- Low hypoxia tolerance as a determinant of the proinflammatory phenotype: a trained immunity perspective.Frontiers in immunology · 2026Review
- Integration of transcriptomics and metabolomics to study the mechanism of Siwei Huangqi powder in Tibetan medicine for protecting against high-altitude hypoxic brain injuries.Journal of traditional and complementary medicine · 2025Article
- Hibernation improves neural performance during energy stress in regions across the central nervous system in the American bullfrog.bioRxiv : the preprint server for biology · 2025Article
- Transient cognitive impacts of oxygen deprivation caused by catch-and-release angling.Biology letters · 2025Article
- Potential for flexible lactate shuttling between astrocytes and neurons to mitigate against diving-induced hypoxia.Frontiers in neuroanatomy · 2025Article
- Refinement of the Antarctic fur seal (Arctocephalus gazella) reference genome increases continuity and completeness.G3 (Bethesda, Md.) · 2024Article
- Neural Processing without OPhysiology (Bethesda, Md.) · 2024Review
- Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers.Physiology (Bethesda, Md.) · 2024Review
- Interference with glutamate antiporter system xExperimental physiology · 2024Article
- Sulfide catabolism in hibernation and neuroprotection.Nitric oxide : biology and chemistry · 2024Review
- Plasticity in the Functional Properties of NMDA Receptors Improves Network Stability during Severe Energy Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Plasticity in the functional properties of NMDA receptors improves network stability during severe energy stress.bioRxiv : the preprint server for biology · 2023Article
- Glutathione Depletion Disrupts Redox Homeostasis in an Anoxia-Tolerant Invertebrate.Antioxidants (Basel, Switzerland) · 2023Article
- Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Many vertebrates are challenged by either chronic or acute episodes of low oxygen availability in their natural environments. Brain function is especially vulnerable to the effects of hypoxia and can be irreversibly impaired by even brief periods of low oxygen supply. This review describes recent research on physiological mechanisms that have evolved in certain vertebrate species to cope with brain hypoxia. Four model systems are considered: freshwater turtles that can survive for months trapped in frozen-over lakes, arctic ground squirrels that respire at extremely low rates during winter hibernation, seals and whales that undertake breath-hold dives lasting minutes to hours, and naked mole-rats that live in crowded burrows completely underground for their entire lives. These species exhibit remarkable specializations of brain physiology that adapt them for acute or chronic episodes of hypoxia. These specializations may be reactive in nature, involving modifications to the catastrophic sequelae of oxygen deprivation that occur in non-tolerant species, or preparatory in nature, preventing the activation of those sequelae altogether. Better understanding of the mechanisms used by these hypoxia-tolerant vertebrates will increase appreciation of how nervous systems are adapted for life in specific ecological niches as well as inform advances in therapy for neurological conditions such as stroke and epilepsy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.