ArticleBlood2014
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
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- EPC1/2 regulate hematopoietic stem and progenitor cell proliferation by modulating H3 acetylation and DLST.iScience · 2024Article
- FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells.Scientific reports · 2023Article
- UpregulatedMolecular therapy oncolytics · 2020Article
- A simple, scalable approach to building a cross-platform transcriptome atlas.PLoS computational biology · 2020Article
- Single‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction.Oncology reports · 2020Article
- The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin.Cells · 2020Article
- Role of HDACs in normal and malignant hematopoiesis.Molecular cancer · 2020Review
- Critical genomic regulation mediated by Enhancer of Polycomb.Current genetics · 2018Review
- Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology.Journal of leukocyte biology · 2017Article
- Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia.Epigenetics · 2017Article
- Article
- The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.BioMed research international · 2015Review
- A regulatory role for CHD2 in myelopoiesis.EpigeneticsArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic differentiation is governed by a complex regulatory program controlling the generation of different lineages of blood cells from multipotent hematopoietic stem cells. The transcriptional program that dictates hematopoietic cell fate and differentiation requires an epigenetic memory function provided by a network of epigenetic factors regulating DNA methylation, posttranslational histone modifications, and chromatin structure. Aberrant interactions between epigenetic factors and transcription factors cause perturbations in the blood cell differentiation program that result in various types of hematopoietic disorders. To elucidate the contributions of different epigenetic factors in human hematopoiesis, high-throughput cap analysis of gene expression was used to build transcription profiles of 199 epigenetic factors in a wide range of blood cells. Our epigenetic transcriptome analysis revealed cell type- (eg, HELLS and ACTL6A), lineage- (eg, MLL), and/or leukemia- (eg, CHD2, CBX8, and EPC1) specific expression of several epigenetic factors. In addition, we show that several epigenetic factors use alternative transcription start sites in different cell types. This analysis could serve as a resource for the scientific community for further characterization of the role of these epigenetic factors in blood development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.