ReviewOpen biology2014
Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila.
Review in Open biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development.Cell reports · 2019Article
- Disruption ofG3 (Bethesda, Md.) · 2018Article
- The GAGA factor regulatory network: Identification of GAGA factor associated proteins.PloS one · 2017Article
- PRE/TRE elements act as transcription activators in Drosophila S2 Cells.Doklady. Biochemistry and biophysics · 2017Article
- Article
- Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.PLoS genetics · 2016Article
- Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Structure and function of histone acetyltransferase MOF.AIMS biophysics · 2015Article
- Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.Genes & development · 2014Article
- Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.Trends in cell biology · 2014Review
- Article
- Polycomb and Trithorax Group Proteins: The Long Road from Mutations in Drosophila to Use in Medicine.Acta naturaeArticle
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Authors and funding
3 authors.
Funding
Abstract
Chromatin-binding proteins must navigate the complex nuclear milieu to find their sites of action, and a constellation of protein factors and other properties are likely to influence targeting specificity. Despite considerable progress, the precise rules by which binding specificity is achieved have remained elusive. Here, we consider early targeting events for two groups of chromatin-binding complexes in Drosophila: the Male-Specific Lethal (MSL) and the Polycomb group (PcG) complexes. These two serve as models for understanding targeting, because they have been extensively studied and play vital roles in Drosophila, and their targets have been documented at high resolution. Furthermore, the proteins and biochemical properties of both complexes are largely conserved in multicellular organisms, including humans. While the MSL complex increases gene expression and PcG members repress genes, the two groups share many similarities such as the ability to modify their chromatin environment to create active or repressive domains, respectively. With legacies of in-depth genetic, biochemical and now genomic approaches, the MSL and PcG complexes will continue to provide tractable systems for understanding the recruitment of multiprotein chromatin complexes to their target loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.