ArticleJournal of the Royal Society, Interface2014
Complex role of space in the crossing of fitness valleys by asexual populations.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Graph-structured populations elucidate the role of deleterious mutations in long-term evolution.Nature communications · 2025Article
- Integration of Immune Cell-Target Cell Conjugate Dynamics Changes the Time Scale of Immune Control of Cancer.Bulletin of mathematical biology · 2025Article
- Diverse mutant selection windows shape spatial heterogeneity in evolving populations.PLoS computational biology · 2024Article
- Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis.Mathematical biosciences · 2023Article
- Diverse mutant selection windows shape spatial heterogeneity in evolving populations.bioRxiv : the preprint server for biology · 2023Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Patient-Specific Mathematical Model of the Clear Cell Renal Cell Carcinoma Microenvironment.Journal of personalized medicine · 2022Article
- Effect of feedback regulation on stem cell fractions in tissues and tumors: Understanding chemoresistance in cancer.Journal of theoretical biology · 2021Article
- Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV.Journal of the Royal Society, Interface · 2020Article
- Limits on amplifiers of natural selection under death-Birth updating.PLoS computational biology · 2020Article
- Environmental spatial and temporal variability and its role in non-favoured mutant dynamics.Journal of the Royal Society, Interface · 2019Article
- The 2019 mathematical oncology roadmap.Physical biology · 2019Review
- Population structure determines the tradeoff between fixation probability and fixation time.Communications biology · 2019Article
- Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution.Journal of the Royal Society, Interface · 2018Article
- Optimizing homeostatic cell renewal in hierarchical tissues.PLoS computational biology · 2018Article
- Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory.Communications biology · 2018Article
- The effect of spatial randomness on the average fixation time of mutants.PLoS computational biology · 2017Article
- Cell dynamics in tumour environment after treatments.Journal of the Royal Society, Interface · 2017Article
- The role of backward cell migration in two-hit mutants' production in the stem cell niche.PloS one · 2017Article
- The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Biology direct · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of complex traits requires the accumulation of multiple mutations, which can be disadvantageous, neutral or advantageous relative to the wild-type. We study two spatial (two-dimensional) models of fitness valley crossing (the constant-population Moran process and the non-constant-population contact process), varying the number of loci involved and the degree of mixing. We find that spatial interactions accelerate the crossing of fitness valleys in the Moran process in the context of neutral and disadvantageous intermediate mutants because of the formation of mutant islands that increase the lifespan of mutant lineages. By contrast, in the contact process, spatial structure can accelerate or delay the emergence of the complex trait, and there can even be an optimal degree of mixing that maximizes the rate of evolution. For advantageous intermediate mutants, spatial interactions always delay the evolution of complex traits, in both the Moran and contact processes. The role of the mutant islands here is the opposite: instead of protecting, they constrict the growth of mutants. We conclude that the laws of population growth can be crucial for the effect of spatial interactions on the rate of evolution, and we relate the two processes explored here to different biological situations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.