Evidence map›Paper›PMID 24671783›Full record

ArticleJournal of clinical microbiology2014

Ureaplasma parvum prosthetic joint infection detected by PCR.

John J Farrell, Joshua A Larson, Jeffrey W Akeson, Kristin S Lowery, Megan A Rounds, Rangarajan Sampath, Robert A Bonomo, Robin Patel

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Diagnostics (Basel, Switzerland) · 2022
    Article
  4. Article
  5. Periprosthetic joint infection withBMJ case reports · 2021
    Article
  6. BMJ case reports · 2021
    Article
  7. Rare case ofBMJ case reports · 2020
    Review
  8. InvasiveOpen forum infectious diseases · 2019
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

John J FarrellUniversity of Illinois School of Medicine, Department of Medicine, Peoria, Illinois, USA jjf@uic.edu.
Joshua A LarsonDivision of Laboratory Medicine, St. Francis Medical Center, Peoria, Illinois, USA.
Jeffrey W AkesonUniversity of Illinois School of Medicine, Department of Orthopedic Surgery, Peoria, Illinois, USA.
Kristin S LoweryIbis Biosciences, Carlsbad, California, USA.
Megan A RoundsIbis Biosciences, Carlsbad, California, USA.
Rangarajan SampathIbis Biosciences, Carlsbad, California, USA.
Robert A BonomoLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, Ohio, USA Case Western Reserve University, Departments of Medicine, Pharmacology and Molecular Microbiology, Cleveland, Ohio, USA.
Robin PatelDivisions of Clinical Microbiology and Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Ionis Pharmaceuticals (United States) · USUniversity of Illinois Urbana-Champaign · USCase Western Reserve University · USMayo Clinic in Florida · USSt. Francis Medical Center · US

Funding

Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
NIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R01AI100560NIAMS NIH HHS R01 AR056647NIAMS NIH HHS R01AR056647
6 · The paper itself

Abstract

We describe the first reported case of Ureaplasma parvum prosthetic joint infection (PJI) detected by PCR. Ureaplasma species do not possess a cell wall and are usually associated with colonization and infection of mucosal surfaces (not prosthetic material). U. parvum is a relatively new species name for certain serovars of Ureaplasma urealyticum, and PCR is useful for species determination. Our patient presented with late infection of his right total knee arthroplasty. Intraoperative fluid and tissue cultures and pre- and postoperative synovial fluid cultures were all negative. To discern the pathogen, we employed PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS). Our patient's failure to respond to empirical antimicrobial treatment and our previous experience with PCR/ESI-MS in culture-negative cases of infection prompted us to use this approach over other diagnostic modalities. PCR/ESI-MS detected U. parvum in all samples. U. parvum-specific PCR testing was performed on all synovial fluid samples to confirm the U. parvum detection.

Indexed as

Polymerase Chain ReactionAgedArthritisArthroplasty, Replacement, KneeHumansMaleMolecular Diagnostic TechniquesProsthesis-Related InfectionsSpectrometry, Mass, Electrospray IonizationSynovial FluidUnited StatesUreaplasmaUreaplasma Infections

Identifiers

PMID24671783
PMCPMC4042745
OpenAlexW2025979709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.