Evidence map›Paper›PMID 24671771›Full record

ArticleAnnals of the rheumatic diseases2015

Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study.

Tim Bongartz, Katrina N Glazebrook, Steven J Kavros, Naveen S Murthy, Stephen P Merry, Walter B Franz, Clement J Michet, Barath M Akkara Veetil, John M Davis, Thomas G Mason and 6 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 115 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 7 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05698680 phase4terminatednot on this mapstarted 2023, after this paper: background citation

Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care

TypeinterventionalSponsorUniversity Medicine GreifswaldRan2023 to 2026Enrolled186ConditionsAcute GoutArmsPrednisolone 30 mg Tablet, Colchicine 0.5 mg Oral Tablet
NCT06024798 unknown statusnot on this mapstarted 2023, after this paper: background citation

Assessing Patients With Suspected Stress or Insufficiency Fracture of the Lower Extremity With Photon-Counting-Computed-Tomography

Typeobservational_patient_registrySponsorBalgrist University HospitalRan2023 to 2025Enrolled50ConditionsStress Fracture Foot, Stress Fracture Ankle, Stress Fracture of Tibia, Stress Fracture MetatarsalArmsPhoton-Counting-Computed-Tomography
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 7 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Patient characteristics, surgical treatment, and outcomes in spinal gout: a systematic review of 315 cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
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  17. Imaging Insights into Midfoot and Forefoot Disorders.Journal of the Korean Society of Radiology · 2025
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Tim BongartzDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Katrina N GlazebrookDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Steven J KavrosDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Naveen S MurthyDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Stephen P MerryDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Walter B FranzDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Clement J MichetDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Barath M Akkara VeetilDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
John M DavisDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Thomas G MasonDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Kenneth J WarringtonDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Steven R YtterbergDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Eric L MattesonDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Cynthia S CrowsonDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Shuai LengDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Cynthia H McColloughDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
WinnMed · USMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the accuracy of dual-energy CT (DECT) for diagnosing gout, and to explore whether it can have any impact on clinical decision making beyond the established diagnostic approach using polarising microscopy of synovial fluid (diagnostic yield).

methodsDiagnostic single-centre study of 40 patients with active gout, and 41 individuals with other types of joint disease. Sensitivity and specificity of DECT for diagnosing gout was calculated against a combined reference standard (polarising and electron microscopy of synovial fluid). To explore the diagnostic yield of DECT scanning, a third cohort was assembled consisting of patients with inflammatory arthritis and risk factors for gout who had negative synovial fluid polarising microscopy results. Among these patients, the proportion of subjects with DECT findings indicating a diagnosis of gout was assessed.

resultsThe sensitivity and specificity of DECT for diagnosing gout was 0.90 (95% CI 0.76 to 0.97) and 0.83 (95% CI 0.68 to 0.93), respectively. All false negative patients were observed among patients with acute, recent-onset gout. All false positive patients had advanced knee osteoarthritis. DECT in the diagnostic yield cohort revealed evidence of uric acid deposition in 14 out of 30 patients (46.7%).

conclusionsDECT provides good diagnostic accuracy for detection of monosodium urate (MSU) deposits in patients with gout. However, sensitivity is lower in patients with recent-onset disease. DECT has a significant impact on clinical decision making when gout is suspected, but polarising microscopy of synovial fluid fails to demonstrate the presence of MSU crystals.

Indexed as

Synovial FluidUric AcidAbsorptiometry, PhotonAdultAgedArthritisCase-Control StudiesCohort StudiesElbow JointFemaleFoot JointsGoutHand JointsHumansKnee JointMaleUric AcidaccuracyDual energy CT scanningGout

Identifiers

PMID24671771
PMCPMC4431329
OpenAlexW2008245966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.