SynthesisEuropean journal of clinical pharmacology2014
Identifying high-risk medication: a systematic literature review.
Synthesis in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness and safety of selected traditional Chinese medicine injections in patients with combined diabetes mellitus and coronary heart disease: A systematic review and network meta-analysis of randomized clinical trials.Frontiers in pharmacology · 2022Pooled it
- Serious adverse drug reactions in sub-Saharan Africa in the era of antiretroviral treatment: A systematic review.Pharmacology research & perspectives · 2021Pooled it
- Trial
- Discrepancies in prescribed medications as reported by patients, general practitioners, and community pharmacists in older patients with polypharmacy in primary care.BMC primary care · 2026Article
- Unintended medication discrepancies across key stages of the in-hospital medication process: a retrospective real-world study in hospitalized patients.BMC health services research · 2026Article
- Medication Safety Risks and Their Management in Finnish Care Units: A Cross-Sectional Survey.Health services insights · 2026Article
- Improving medication safety in the perioperative setting: development of a medication use process.British journal of anaesthesia · 2025Article
- A National Study Among Diverse US Populations of Exposure to Prescription Medications with Evidence-Based Pharmacogenomic Information.Clinical pharmacology and therapeutics · 2025Article
- "Doctor, would it surprise you if there were prescribing errors in this patient's medication?" Identifying eligible patients for in-hospital pharmacotherapeutic stewardship: A matched case-control study.British journal of clinical pharmacology · 2025Article
- Operation Polypharmacy: a pharmacist-led ambulatory care clinic design and evaluation for older patients.Scientific reports · 2024Article
- Excessive Self-Medication with Prescription NSAIDs: A Cross-Sectional Study in Kosovo.Pharmacy (Basel, Switzerland) · 2024Article
- Identifying interventions that improve medication safety & rational use of medicines in India.The Indian journal of medical research · 2024Article
- A quality improvement study of the implementation and initial results of a pragmatic clinical decision support system in the community pharmacy setting.International journal of clinical pharmacy · 2024Observational
- Article
- Clinical frailty and polypharmacy in older emergency critical care patients: a single-centre retrospective case series.European journal of hospital pharmacy : science and practice · 2023Article
- Prioritizing patients for medication review by emergency department pharmacists: a multi-method study.International journal of clinical pharmacy · 2023Article
- Evaluation of a multifaceted medication review in older patients in the outpatient setting: a before-and-after study.International journal of clinical pharmacy · 2023Article
- Drug-Related Problems in Bariatric Surgery: a Retrospective Study.Obesity surgery · 2022Article
- Prescribing errors in post - COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post - COVID-19 outpatient clinic.BMC emergency medicine · 2022Observational
- A prediction and interpretation machine learning framework of mortality risk among severe infection patients with pseudomonas aeruginosa.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA medication error (ME) is an error that causes damage or poses a threat of harm to a patient. Several studies have shown that only a minority of MEs actually causes harm, and this might explain why medication reviews at hospital admission reduce the number of MEs without showing an effect on length of hospital stay, readmissions, or death. The purpose of this study was to define drugs that actually cause serious MEs. We conducted a literature search of medication reviews and other preventive efforts.
methodsA systematic search in PubMed, Embase, Cochrane Reviews, Psycinfo, and SweMed+ was performed. Danish databases containing published patient complaints, patient compensation, and reported medication errors were also searched. Articles and case reports were included if they contained information of an ME causing a serious adverse reaction (AR) in a patient. Information concerning AR seriousness, causality, and preventability was required for inclusion.
resultsThis systematic literature review revealed that 47 % of all serious MEs were caused by seven drugs or drug classes: methotrexate, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDS), digoxin, opioids, acetylic salicylic acid, and beta-blockers; 30 drugs or drug classes caused 82 % of all serious MEs. The top ten drugs involved in fatal events accounted for 73 % of all drugs identified.
conclusionIncreasing focus on seven drugs/drug classes can potentially reduce hospitalizations, extended hospitalizations, disability, life-threatening conditions, and death by almost 50 %.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.