ReviewCurrent pain and headache reports2014
Migraine and reward system-or is it aversive?
Review in Current pain and headache reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Atogepant modulates brain connectivity in episodic migraine: a longitudinal exploratory fMRI study.Frontiers in neurology · 2026Article
- Pathophysiological changes in incentive processing in episodic migraine: a preliminary event-related potential study.Social cognitive and affective neuroscience · 2025Article
- How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review.Journal of personalized medicine · 2024Review
- Meditation Practice, Mindfulness, and Pain-Related Outcomes in Mindfulness-Based Treatment for Episodic Migraine.Mindfulness · 2023Article
- Contributions of aversive environmental stress to migraine chronification: Research update of migraine pathophysiology.World journal of clinical cases · 2021Review
- Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine.Journal of pain research · 2021Article
- Modulation of the Negative Affective Dimension of Pain: Focus on Selected Neuropeptidergic System Contributions.International journal of molecular sciences · 2019Review
- Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Altered neural activity to monetary reward/loss processing in episodic migraine.Scientific reports · 2019Article
- Neuroinflammation-a co-occurring phenomenon linking chronic pain and opioid dependence.Current opinion in behavioral sciences · 2017Article
- Reward Circuitry Plasticity in Pain Perception and Modulation.Frontiers in pharmacology · 2017Review
- Does the kappa opioid receptor system contribute to pain aversion?Frontiers in pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain regions within pain and reward circuitry that contribute to negative affect and subjective experience of pain. The emotional component of pain has been argued to be a greater metric of quality of life than its sensory component, and thus understanding the processes that influence this pain characteristic is essential to developing novel treatment strategies for mitigating migraine pain. We emphasize and provide evidence that abnormalities within the mesolimbic cortical reward pathways contribute to migraine pain and that there are structural and functional neuroplasticity within the overlapping brain regions common to both pain and reward.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.