ReviewCurrent osteoporosis reports2014
The effects of flavonoids on bone.
Review in Current osteoporosis reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- The Role of Diet in Osteoporotic Fracture Healing: a Systematic Review.Current osteoporosis reports · 2020Pooled it
- Flavonoids, Chalcones, and Their Fluorinated Derivatives-Recent Advances in Synthesis and Potential Medical Applications.Molecules (Basel, Switzerland) · 2025Review
- Review on antibacterial flavonoids from genusHeliyon · 2025Review
- Nrf2 Activation as a Therapeutic Target for Flavonoids in Aging-Related Osteoporosis.Nutrients · 2025Review
- Plant-derived food bioactives in bone health: from multi-targeted roles to molecular mechanisms in osteoporosis.Frontiers in nutrition · 2025Review
- Review
- Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis).Journal of bone metabolism · 2024Article
- The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects.International journal of molecular sciences · 2024Review
- Diversity of the diet is correlated with osteoporosis in post-menopausal women: an Iranian case-control study.Frontiers in public health · 2024Article
- Review
- Hesperidin Anti-Osteoporosis by Regulating Estrogen Signaling Pathways.Molecules (Basel, Switzerland) · 2023Article
- Biological Properties and Antimicrobial Potential of Cocoa and Its Effects on Systemic and Oral Health.Nutrients · 2023Review
- Review
- Catechins and Proanthocyanidins Involvement in Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss.Nutrients · 2023Review
- Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition.Journal of agricultural and food chemistry · 2023Article
- A synthetic peptide from Sipunculus nudus promotes bone formation via Estrogen/MAPK signal pathway based on network pharmacology.Frontiers in pharmacology · 2023Article
- Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic - angiogenic coupling effect via Wnt/ β-catenin pathway.Materials today. Bio · 2022Article
- Evaluation of the osteogenic effect of apigenin on human mesenchymal stem cells by inhibiting inflammation through modulation of NF-κB/IκBα.Research in pharmaceutical sciences · 2022Article
- Polyphenolic Compounds Inhibit Osteoclast Differentiation While Reducing Autophagy through Limiting ROS and the Mitochondrial Membrane Potential.Biomolecules · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis and fragility fractures are a growing problem for our aging population with around 1 in 2 women and 1 in 5 men suffering from an osteoporotic fracture during their lifetime. Although there are established factors that can reduce the risk of fracture such as maintaining physical activity, ceasing smoking, and adequate vitamin D status, and intakes of calcium; dietary mechanisms are less well established. The relevance of the flavonoid group of bioactive compounds found in fruits and vegetables has been less investigated. Two human epidemiologic studies in women found positive associations between total dietary flavonoid intake and bone mineral density. Flavonoids may protect against bone loss by upregulating signaling pathways that promote osteoblast function, by reducing the effects of oxidative stress or chronic low-grade inflammation. The limitations of the existing research are explored in the manuscript and it is concluded that further research is needed, in this promising area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.