ArticleDiabetologia2014
Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The functional foetal brain: A systematic review and meta-analysis.Developmental cognitive neuroscience · 2026Pooled it
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Maternal Nutrition and Hypothalamic Programming of Offspring Metabolic Health.The Journal of nutrition · 2026Review
- Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.Scientific reports · 2025Article
- Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia.The Journal of endocrinology · 2022Review
- Evaluation of parameters for fetal behavioural state classification.Scientific reports · 2022Article
- Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices.Clinical medicine insights. Endocrinology and diabetes · 2022Article
- Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function.Frontiers in endocrinology · 2022Review
- Neonatal amygdala microstructure mediates the relationship between gestational glycemia and offspring adiposity.BMJ open diabetes research & care · 2021Article
- No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes.Nutrients · 2021Article
- Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography.Clinical EEG and neuroscience · 2020Observational
- A pilot study: Auditory steady-state responses (ASSR) can be measured in human fetuses using fetal magnetoencephalography (fMEG).PloS one · 2020Article
- Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain.Diabetes care · 2019Article
- Evaluating Complexity of Fetal MEG Signals: A Comparison of Different Metrics and Their Applicability.Frontiers in systems neuroscience · 2019Article
- Epigenetic Programming and Fetal Metabolic Programming.Frontiers in endocrinology · 2019Review
- Editorial: Insulin and The Brain.Frontiers in endocrinology · 2019Article
- Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice.Diabetologia · 2018Article
- Family History of Diabetes Is Associated With Delayed Fetal Postprandial Brain Activity.Frontiers in endocrinology · 2018Article
- Brain heparan sulphate proteoglycans are altered in developing foetus when exposed to in-utero hyperglycaemia.Metabolic brain disease · 2017Article
- Insulin resistance in Alzheimer's disease.Translational research : the journal of laboratory and clinical medicine · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisFetal programming plays an important role in the pathogenesis of type 2 diabetes. The aim of the present study was to investigate whether maternal metabolic changes during OGTT influence fetal brain activity.
methodsThirteen healthy pregnant women underwent an OGTT (75 g). Insulin sensitivity was determined by glucose and insulin measurements at 0, 60 and 120 min. At each time point, fetal auditory evoked fields were recorded with a fetal magnetoencephalographic device and response latencies were determined.
resultsMaternal insulin increased from a fasting level of 67 ± 25 pmol/l (mean ± SD) to 918 ± 492 pmol/l 60 min after glucose ingestion and glucose levels increased from 4.4 ± 0.3 to 7.4 ± 1.1 mmol/l. Over the same time period, fetal response latencies decreased from 297 ± 99 to 235 ± 84 ms (p = 0.01) and then remained stable until 120 min (235 ± 84 vs 251 ± 91 ms, p = 0.39). There was a negative correlation between maternal insulin sensitivity and fetal response latencies 60 min after glucose ingestion (r = 0.68, p = 0.02). After a median split of the group based on maternal insulin sensitivity, fetuses of insulin-resistant mothers showed a slower response to auditory stimuli (283 ± 79 ms) than those of insulin-sensitive mothers (178 ± 46 ms, p = 0.03). CONCLUSIONS/
interpretationLower maternal insulin sensitivity is associated with slower fetal brain responses. These findings provide the first evidence of a direct effect of maternal metabolism on fetal brain activity and suggest that central insulin resistance may be programmed during fetal development.
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