ArticlePloS one2014
Longitudinal association between body mass index and health-related quality of life.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00379249 (Effects of a Twelve Months ROSUVASTATIN Treatment Plus Additional Care), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Twelve Months ROSUVASTATIN Treatment Plus Additional Care (Drug Intake Adherence and Lifestyle Enhancing Initiatives ) Compared to ROSUVASTATIN Treatment Alone on Long-Term Disease-Related Costs in Patients With an Indication for Statin Treatment According to the Joint European Guidelines
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Strategies to improve smoking cessation rates in primary care.The Cochrane database of systematic reviews · 2021Pooled it
- Disentangling direct and weight-mediated effects of physical activity on health-related quality of life in a 12-month real-world digital lifestyle intervention.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Is alexithymia associated with weight-related self-esteem after metabolic and bariatric surgery: A cross-sectional study.Medicine · 2026Observational
- Tirzepatide Was Associated with Improved Health-Related Quality of Life in Adults with Obesity or Overweight and Type 2 Diabetes: Results from the Phase 3 SURMOUNT-2 Trial.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- No Obesity Paradox for Health-Related Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Insights from the VIDA Multicenter Study.Journal of clinical medicine · 2024Article
- Scuba diving fatalities in Australia, 2001 to 2013: Diver demographics and characteristics.Diving and hyperbaric medicine · 2020Article
- Associations between perceived environmental pollution and health-related quality of life in a Chinese adult population.Health and quality of life outcomes · 2020Article
- A bi-directional association between weight change and health-related quality of life: evidence from the 11-year follow-up of 9916 community-dwelling adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Snorkelling and breath-hold diving fatalities in Australia, 2001 to 2013. Demographics, characteristics and chain of events.Diving and hyperbaric medicine · 2019Article
- Cost-Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis.Arthritis care & research · 2019Article
- Impaired health-related quality of life and related risk factors among US adults with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
- Health-related quality of life in adolescents and the retinal microvascular structure.Scientific reports · 2018Article
- The impact of obesity on health-related quality of life in Spain.Health and quality of life outcomes · 2017Article
- Article
- Main predictors in health-related quality of life in Chinese patients with type 2 diabetes mellitus.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Body mass index and health status in diabetic and non-diabetic individuals.Nutrition & diabetes · 2015Article
- Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011).Health and quality of life outcomes · 2015Article
- Gender differences in health-related quality of life in patients undergoing coronary angiography.Open heartArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHealth-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity.
designSecondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy.
methodsHRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time.
resultsOf the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (β [95% CI] per 1 kg/m2: -0.36 [-0.41; -0.30] and -0.05 [-0.11; -0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (-0.18 [-0.27; -0.09]) and only in obese participants (-0.19 [-0.29; -0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population.
conclusionIncreases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status.
trial registrationClinicalTrials.gov NCT00379249.
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