ArticleThe ISME journal2014
Phages can constrain protist predation-driven attenuation of Pseudomonas aeruginosa virulence in multienemy communities.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
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- Central carbon metabolism switching in lytic versus temperate coral reef viral communities.bioRxiv : the preprint server for biology · 2025Article
- Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs.Microbiology (Reading, England) · 2025Article
- Making a Pathogen? Evaluating the Impact of Protist Predation on the Evolution of Virulence in Serratia marcescens.Genome biology and evolution · 2024Article
- Temperature-dependent trophic associations modulate soil bacterial communities along latitudinal gradients.The ISME journal · 2024Article
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- Two Predators, One Prey - the Interaction Between Bacteriophage, Bacterivorous Ciliates, and Escherichia coli.Microbial ecology · 2023Article
- Rhizosphere phage communities drive soil suppressiveness to bacterial wilt disease.Microbiome · 2023Article
- [Research advances on the interaction betweenZhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence.Applied and environmental microbiology · 2022Article
- Adaptation to an amoeba host drives selection of virulence-associated traits in Vibrio cholerae.The ISME journal · 2022Article
- Community and single cell analyses reveal complex predatory interactions between bacteria in high diversity systems.Nature communications · 2021Article
- Article
- Phage combination therapies for bacterial wilt disease in tomato.Nature biotechnology · 2019Article
- Host-pathogen coevolution in the presence of predators: fluctuating selection and ecological feedbacks.Proceedings. Biological sciences · 2018Article
- Review
- Ecology determines how low antibiotic concentration impacts community composition and horizontal transfer of resistance genes.Communications biology · 2018Article
- Parasites and competitors suppress bacterial pathogen synergistically due to evolutionary trade-offs.Evolution; international journal of organic evolution · 2017Article
- Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of modelEvolutionary applications · 2017Article
- Synergistic Interactions within a Multispecies Biofilm Enhance Individual Species Protection against Grazing by a Pelagic Protozoan.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The coincidental theory of virulence predicts that bacterial pathogenicity could be a by-product of selection by natural enemies in environmental reservoirs. However, current results are ambiguous and the simultaneous impact of multiple ubiquitous enemies, protists and phages on virulence evolution has not been investigated previously. Here we tested experimentally how Tetrahymena thermophila protist predation and PNM phage parasitism (bacteria-specific virus) alone and together affect the evolution of Pseudomonas aeruginosa PAO1 virulence, measured in wax moth larvae. Protist predation selected for small colony types, both in the absence and presence of phage, which showed decreased edibility to protists, reduced growth in the absence of enemies and attenuated virulence. Although phage selection alone did not affect the bacterial phenotype, it weakened protist-driven antipredatory defence (biofilm formation), its associated pleiotropic growth cost and the correlated reduction in virulence. These results suggest that protist selection can be a strong coincidental driver of attenuated bacterial virulence, and that phages can constrain this effect owing to effects on population dynamics and conflicting selection pressures. Attempting to define causal links such as these might help us to predict the cold and hot spots of coincidental virulence evolution on the basis of microbial community composition of environmental reservoirs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.