ReviewCurrent opinion in supportive and palliative care2014
Serotonin, 5HT1 agonists, and migraine: new data, but old questions still not answered.
Review in Current opinion in supportive and palliative care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- Review
- Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study.The journal of headache and pain · 2020Article
- Functional gene networks reveal distinct mechanisms segregating in migraine families.Brain : a journal of neurology · 2020Article
- Probiotics for the Prophylaxis of Migraine: A Systematic Review of Randomized Placebo Controlled Trials.Journal of clinical medicine · 2019Review
- Histamine and migraine revisited: mechanisms and possible drug targets.The journal of headache and pain · 2019Review
- Recognition and Optimization of Ingredients Treating Nitroglycerin-Induced Migraine Rats from Wuzhuyu Decoction.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Genetic and biochemical changes of the serotonergic system in migraine pathobiology.The journal of headache and pain · 2017Review
- Article
- The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study.PloS one · 2017Article
- Neurovascular contributions to migraine: Moving beyond vasodilation.Neuroscience · 2016Review
- Resting-state fMRI study of acute migraine treatment with kinetic oscillation stimulation in nasal cavity.NeuroImage. Clinical · 2016Article
- ASICs as therapeutic targets for migraine.Neuropharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe serotonergic system has long been linked to migraine but recent studies highlight how much is still unclear about this link. And recent data add to the uncertainty of where/how triptans act and why they are headache specific. RECENT
findingsMarkers of 5HT levels in the brains of migraine patients show no changes between attacks. Several recent meta-analyses show the most convincing data on genetic differences in the serotonergic system for 5HT transporters. Findings of additional triptan actions on peripheral trigeminovascular neurons and in the hypothalamus add more fuel to the debate on where these drugs act. A growing list of studies show efficacy of multiple triptans and other 5HT1b/1d agonists in preclinical models of nonheadache pain arguing for reevaluation of whether these drugs have efficacy in other pain states. Despite these issues, serotonergic drugs continue to be the gold standard for abortive agents with new members on the horizon (5HT1f agonists). SUMMARY: Given the clear efficacy of serotonergic drugs for migraine, continued study on the role of the endogenous 5HT system may lead to more novel therapies. And with the list of studies demonstrating efficacy triptans in models of nonheadache, clinical studies should address whether these drugs work for other types of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.