ArticleJournal of immunology (Baltimore, Md. : 1950)2014
A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K.Scientific reports · 2023Article
- Semaphorin 3A: A potential target for prevention and treatment of nickel allergy.Communications biology · 2022Article
- Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling.Journal of clinical medicine · 2022Article
- Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity duringInternational journal of ophthalmology · 2021Article
- Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner.PloS one · 2021Article
- Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities.Scientific reports · 2020Article
- TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway.Journal of clinical medicine · 2019Article
- Article
- GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen.Mucosal immunology · 2017Article
- Molecular Mechanisms of Nickel Allergy.International journal of molecular sciences · 2016Review
- Specific Induction of TSLP by the Viral RNA Analogue Poly(I:C) in Primary Epithelial Cells Derived from Nasal Polyps.PloS one · 2016Article
- Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway.Clinical and translational allergy · 2015Article
- Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases.Anais brasileiros de dermatologiaObservational
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ni is the most frequent cause of contact allergy induced by metals. However, the underlying mechanism of this induction is unknown. Our previous research demonstrates that activation of dendritic cells (DCs) through p38MAPK/MKK6 is required for Ni-induced allergy in mice. In the current study, we investigated the cellular and molecular mechanisms underlying Ni-induced allergy using a mouse model that involves injecting Ni into the ear, with or without Freund's incomplete or complete adjuvants. Nickel had greater potential to cause allergic reactions compared with palladium and gold. Among the proteins expressed at higher levels in mice with Ni-induced allergy, we focused on thymic stromal lymphopoietin (TSLP), which is produced in abundance by keratinocytes. We detected increased expression of the TSLP receptor (TSLPR) in DCs from cervical lymph nodes of mice with Ni-induced allergy, suggesting that DCs in ear tissues were activated through TSLPR signaling induced by keratinocyte-derived TSLP. Furthermore, delayed-type hypersensitivity reactions in mice with Ni-induced allergy were decreased significantly by injection of a Tslp-short interfering RNA along with atelocollagen in the ear skin. These results suggest that Ni allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells.
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