ArticleScientific reports2014
Active transport of vesicles in neurons is modulated by mechanical tension.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Mechanical forces stimulate Golgi export.The Journal of cell biology · 2026Article
- A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles.JCI insight · 2025Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization.Brain communications · 2023Article
- Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction.The Journal of cell biology · 2022Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Impact of neurite alignment on organelle motion.Journal of the Royal Society, Interface · 2022Article
- Deformation of microtubules regulates translocation dynamics of kinesin.Science advances · 2021Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Modelling the motion of organelles in an elongated cell via the coordination of heterogeneous drift-diffusion and long-range transport.The European physical journal. E, Soft matter · 2021Article
- Manipulation of Axonal Outgrowth via Exogenous Low Forces.International journal of molecular sciences · 2020Review
- Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm.Developmental cell · 2020Article
- Lysosome Dynamic Properties during Neuronal Stem Cell Differentiation Studied by Spatiotemporal Fluctuation Spectroscopy and Organelle Tracking.International journal of molecular sciences · 2020Article
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth.PLoS computational biology · 2019Article
- Small-scale displacement fluctuations of vesicles in fibroblasts.Scientific reports · 2018Article
- Cytoskeletal Mechanisms of Axonal Contractility.Biophysical journal · 2018Article
- Non-invasive Neurite Mechanics in Differentiated PC12 Cells.Frontiers in cellular neuroscience · 2018Article
- Activity-Dependence of Synaptic Vesicle Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots.Chemical Society reviews · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective intracellular transport of proteins and organelles is critical in cells, and is especially important for ensuring proper neuron functionality. In neurons, most proteins are synthesized in the cell body and must be transported through thin structures over long distances where normal diffusion is insufficient. Neurons transport subcellular cargo along axons and neurites through a stochastic interplay of active and passive transport. Mechanical tension is critical in maintaining proper function in neurons, but its role in transport is not well understood. To this end, we investigate the active and passive transport of vesicles in Aplysia neurons while changing neurite tension via applied strain, and quantify the resulting dynamics. We found that tension in neurons modulates active transport of vesicles by increasing the probability of active motion, effective diffusivity, and induces a retrograde bias. We show that mechanical tension modulates active transport processes in neurons and that external forces can couple to internal (subcellular) forces and change the overall transport dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.