ArticlePloS one2014
Expression of adrenoceptor subtypes in preterm piglet heart is different to term heart.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Epinephrine versus dopamine in neonatal septic shock: a double-blind randomized controlled trial.European journal of pediatrics · 2018Trial
- Deferred cord clamping in twin pregnancies: benefit, risk, or missed opportunity? A narrative review.Resuscitation plus · 2026Review
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia.Clinical science (London, England : 1979) · 2025Article
- Dexmedetomidine's effect on neonatal sedation, pain, respiratory status and cardiovascular system.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Ductus Arteriosus in Fetal and Perinatal Life.Journal of cardiovascular development and disease · 2024Review
- Impact of prematurity on lifelong cardiovascular health: structural and functional considerations.NPJ cardiovascular health · 2024Review
- Preterm pigs for preterm birth research: reasonably feasible.Frontiers in physiology · 2023Review
- Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic.The Journal of physiology · 2018Article
- Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.Pediatric research · 2018Article
- Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants.Pediatric research · 2016Article
- Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets.Pediatric research · 2016Article
- Fetal Physiology and the Transition to Extrauterine Life.Clinics in perinatology · 2016Review
- Article
- Is the ferret a suitable species for studying perinatal brain injury?International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2015Review
- Endogenous angiotensins and catecholamines do not reduce skin blood flow or prevent hypotension in preterm piglets.Physiological reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm delivery increases the risk of inadequate systemic blood flow and hypotension, and many preterm infants fail to respond to conventional inotrope treatments. If the profile of cardiac adrenoceptor subtypes in the preterm neonate is different to that at term this may contribute to these clinical problems. This study measured mRNA expression of β1, β2, α1A, α2A and α2B-adrenoceptor subtypes by real time PCR in term (113d), preterm (91d) and preterm piglets (91d) exposed to maternal glucocorticoid treatment. Abundance of β-adrenoceptor binding sites in the left ventricle was measured using saturation binding assays. Relative abundance of β1-adrenoceptor mRNA in untreated preterm hearts was ∼50% of term abundance in both left and right ventricles (P<0.001). Trends in receptor binding site density measurements supported this observation (P = 0.07). Glucocorticoid exposure increased β1-adrenoceptor mRNA levels in the right ventricle of preterm hearts (P = 0.008) but did not alter expression in the left ventricle (P>0.1). Relative abundance of α1A-adrenoceptor mRNA was the same in preterm and term piglet hearts (P = >0.1) but was reduced by maternal glucocorticoid treatment (P<0.01); α2A-adrenoceptor mRNA abundance was higher in untreated and glucocorticoid exposed preterm piglet hearts than in term piglets (P<0.001). There was no difference between male and female piglets in mRNA abundance of any of the genes studied. In conclusion, there is reduced mRNA abundance of β1-adrenoceptors in the preterm pig heart. If this lower expression of β-adrenoceptors occurs in human preterm infants, it could explain their poor cardiovascular function and their frequent failure to respond to commonly used inotropes.
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