Evidence map›Paper›PMID 24670609›Full record

ArticleNeuro-oncology2014

Increased tryptophan uptake on PET has strong independent prognostic value in patients with a previously treated high-grade glioma.

David O Kamson, Sandeep Mittal, Natasha L Robinette, Otto Muzik, William J Kupsky, Geoffrey R Barger, Csaba Juhász

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

David O KamsonPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
Sandeep MittalPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
Natasha L RobinettePET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
Otto MuzikPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
William J KupskyPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
Geoffrey R BargerPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
Csaba JuhászPET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI (D.O.K., O.M., C.J.); Department of Neurology, Wayne State University, Detroit, Michigan (G.R.B., C.J.); Department of Neurosurgery, Wayne State University, Detroit, Michigan (S.M.); Department of Oncology, Wayne State University, Detroit, Michigan (S.M.); Department of Pathology, Wayne State University, Detroit, Michigan (W.J.K.); Department of Pediatrics, Wayne State University, Detroit, Michigan (O.M., C.J.); Department of Radiology, Wayne State University, Detroit, Michigan (N.L.R., O.M.); Karmanos Cancer Institute, Detroit, Michigan (S.M., N.L.R., W.J.K., G.R.B., C.J.).
The Barbara Ann Karmanos Cancer Institute · USChildren's Hospital of Michigan · USDetroit Medical Center · USWayne State University · US

Funding

Tryptophan Metabolism in Human Brain TumorsR01CA123451 · NCI · WAYNE STATE UNIVERSITY · PI JUHASZ, CSABA, MITTAL, SANDEEP · 2008 to 2018
$3.1M
NCI NIH HHS R01 CA123451
6 · The paper itself

Abstract

backgroundPreviously, we demonstrated the high accuracy of alpha-[(11)C]methyl-L-tryptophan (AMT) PET for differentiating recurrent gliomas from radiation injury. The present study evaluated the prognostic value of increased AMT uptake in patients with previously treated high-grade glioma.

methodsAMT-PET was performed in 39 patients with suspected recurrence of World Health Organization grades III-IV glioma following surgical resection, radiation, and chemotherapy. Mean and maximum standardized uptake values (SUVs) and unidirectional AMT uptake (K) were measured in brain regions suspicious for tumor and compared with the contralateral cortex (ie, background). Optimal cutoff thresholds for 1-year survival prediction were determined for each AMT parameter and used for calculating the prognostic value of high (above threshold) versus low (below threshold) values for post-PET overall survival (OS).

resultsIn univariate analyses, 1-year survival was strongly associated with 3 AMT parameters (SUVmax, SUVmean, and tumor-to-background K-ratio; odds ratios: 21.3-25.6; P ≤ .001) and with recent change in MRI contrast enhancement (odds ratio: 14.7; P = .02). Median OS was 876 days in the low- versus 177 days in the high-AMT groups (log-rank P < .001). In multivariate analyses, all 3 AMT parameters remained strong predictors of survival: high AMT values were associated with unfavorable 1-year survival (binary regression P ≤ .003) and shorter overall survival in the whole group (Cox regression hazard ratios: 5.3-10.0) and in patients with recent enhancement change on MRI as well (hazard ratios: 7.0-9.3; P ≤ .001).

conclusionIncreased AMT uptake on PET is highly prognostic for 1-year and overall survival, independent of MRI contrast enhancement and other prognostic factors in patients with a previously treated high-grade glioma.

Indexed as

Positron-Emission TomographyAdultAgedAged, 80 and overBrain NeoplasmsCarbon RadioisotopesFemaleGliomaHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvival AnalysisTryptophanCarbon RadioisotopesTryptophanamino acid PEThigh-grade gliomaMRIsurvivaltryptophan

Identifiers

PMID24670609
PMCPMC4165412
OpenAlexW2143624345

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