Observational studyAIDS (London, England)2014
HIV therapy, metabolic and cardiovascular health are associated with glomerular hyperfiltration among men with and without HIV infection.
Observational study in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- In the Mismatch: Viral Suppression Despite Low Tenofovir-Diphosphate in Dried Blood Spots in the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Feasibility of Emergency Department-Initiated HIV Pre-Exposure Prophylaxis.The western journal of emergency medicine · 2024Article
- Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease.Nephron · 2024Review
- Validation of a simple equation for glomerular filtration rate measurement based on plasma iohexol disappearance.Clinical kidney journal · 2020Article
- Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation.Pediatric nephrology (Berlin, Germany) · 2019Observational
- Long-term kidney function, proteinuria, and associated risks among HIV-infected and uninfected men.AIDS (London, England) · 2018Article
- Relationships of Measured Iohexol GFR and Estimated GFR With CKD-Related Biomarkers in Children and Adolescents.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Inflammation, Immune Activation, Immunosenescence, and Hormonal Biomarkers in the Frailty-Related Phenotype of Men With or at Risk for HIV Infection.The Journal of infectious diseases · 2017Article
- Renal abnormalities in a cohort of HIV-infected children and adolescents.Pediatric nephrology (Berlin, Germany) · 2016Article
- Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals.AIDS (London, England) · 2016Article
- Associations between plasma tenofovir concentration and renal function markers in HIV-infected women.Southern African journal of HIV medicine · 2016Article
- Kidney Dysfunction and Markers of Inflammation in the Multicenter AIDS Cohort Study.The Journal of infectious diseases · 2015Article
- Proteinuria is associated with neurocognitive impairment in antiretroviral therapy treated HIV-infected individuals.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Identifying the appropriate comparison group for HIV-infected individuals.Current opinion in HIV and AIDS · 2014Review
- A 10-year follow-up study of demographic and cardiometabolic factors in HIV-infected South Africans.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveDiabetes and hypertension, common conditions in antiretroviral-treated HIV-infected individuals, are associated with glomerular hyperfiltration, which precedes the onset of proteinuria and accelerated kidney function decline. In the Multicenter AIDS Cohort Study, we examined the extent to which hyperfiltration is present and associated with metabolic, cardiovascular, HIV and treatment risk factors among HIV-infected men.
designCross-sectional cohort using direct measurement of glomerular filtration rate by iohexol plasma clearance for 367 HIV-infected men and 241 HIV-uninfected men who were free of chronic kidney disease.
methodsHyperfiltration was defined as glomerular filtration rate above 140-1 ml/min per 1.73 m per year over age 40. Multivariate logistic regression was used to estimate the odds ratios (ORs) of prevalent hyperfiltration for metabolic, cardiovascular, HIV and cumulative antiretroviral exposure factors.
resultsAmong individuals without chronic kidney disease, the prevalence of hyperfiltration was higher for HIV-infected participants (25%) compared to uninfected participants (17%; P = 0.01). After adjustment, HIV infection remained associated with hyperfiltration [OR 1.70, 95% confidence interval (CI) 1.11-2.61] and modified the association between diabetes and hyperfiltration, such that the association among HIV-uninfected men (OR 2.56, 95% CI 1.33-5.54) was not observed among HIV-infected men (OR 1.19, 95% CI 0.69-2.05). These associations were independent of known risk factors for hyperfiltration. Indicators of hyperglycemia and hypertension were also associated with hyperfiltration as was cumulative zidovudine exposure.
conclusionHyperfiltration, a potential modifiable predictor of kidney disease progression, is significantly higher among antiretroviral-treated HIV-infected men. Furthermore, HIV-infection nullifies the association of diabetes and hyperfiltration present in HIV-uninfected men.
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