Observational studyBMJ open2014
Feasibility of aerosol drug delivery to sleeping infants: a prospective observational study.
Observational study in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01120938 (Do Pacifiers Protect From Sudden Infant Death Syndrome), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Do Pacifiers Protect From Sudden Infant Death Syndrome (SIDS) Through an Increase in Upper Airway Patency?
Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- A path to successful patient outcomes through aerosol drug delivery to children: a narrative review.Annals of translational medicine · 2021Review
- Mask Use with Spacers/Valved Holding Chambers and Metered Dose Inhalers among Children with Asthma.Annals of the American Thoracic Society · 2021Review
- Aerosol Therapy in Asthma-Why We Are Failing Our Patients and How We Can Do Better.Frontiers in pediatrics · 2020Review
- Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.International journal of molecular sciences · 2019Review
- Medication Regimens for Managing COPD Exacerbations.Respiratory care · 2018Review
- Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children.World journal of clinical pediatrics · 2016Review
- Challenges Associated with Route of Administration in Neonatal Drug Delivery.Clinical pharmacokinetics · 2016Review
- Comment on "Optimizing the Delivery of Inhaled Medication for Respiratory Patients: The Role of Valved Holding Chambers".Canadian respiratory journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDelivery of inhaled medications to infants is usually very demanding and is often associated with crying and mask rejection. It has been suggested that aerosol administration during sleep may be an attractive alternative. Previous studies in sleeping children were disappointing as most of the children awoke and rejected the treatment. The SootherMask (SM) is a new, gentle and innovative approach for delivering inhaled medication to infants and toddlers. The present pilot study describes the feasibility of administering inhaled medications during sleep using the SM.
designProspective observational study.
settingOut patients.
participants13 sleeping infants with recurrent wheezing who regularly used pacifiers and were <12 months old.
interventionParticipants inhaled technetium99mDTPA-labelled normal saline aerosol delivered via a Respimat Soft Mist Inhaler (SMI) (Boehringer-Ingelheim, Germany) and SM + InspiraChamber (IC; InspiRx Inc, New Jersey, USA). OUTCOMES: The two major outcomes were the acceptability of the treatment and the lung deposition (per cent of emitted dose).
resultsAll infants who fulfilled the inclusion criteria successfully received the SM treatment during sleep without difficulty. Mean lung deposition (±SD) averaged 1.6±0.5% in the right lung.
conclusionsThis study demonstrated that the combination of Respimat, IC and SM was able to administer aerosol therapy to all the sleeping infants who were regular pacifier users with good lung deposition. Administration of aerosols during sleep is advantageous since all the sleeping children accepted the mask and ensuing aerosol therapy under these conditions, in contrast to previous studies in which there was frequent mask rejection using currently available devices. CLINICAL TRIAL REGISTRY: NCT01120938.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.