ArticleMucosal immunology2014
Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis.
Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- A special multifiber dietary mixture ameliorates Crohn's-like colitis in an IL-10European journal of nutrition · 2026Article
- Pharmacogenetics Role of Genetic Variants in Immune-Related Factors: A Systematic Review Focusing on mCRC.Pharmaceutics · 2022Review
- Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response.The Journal of infectious diseases · 2022Article
- Protective and Anti-Inflammatory Effects of Protegrin-1 onInternational journal of molecular sciences · 2021Article
- Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease.Gut microbes · 2020Article
- MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease.Mucosal immunology · 2020Article
- Subclinical Nasal and Lung Lymphocytosis in Ulcerative Colitis.Inflammatory intestinal diseases · 2019Article
- Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission.Current immunology reviews · 2019Article
- TGF-β-mediated enhancement of TScience signaling · 2018Article
- Immunomodulatory Protein Hydrolysates and Their Application.Nutrients · 2018Review
- Toll-like Receptors and Inflammatory Bowel Disease.Frontiers in immunology · 2018Review
- Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population.PloS one · 2018Article
- Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11cScientific reports · 2017Article
- In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses.PloS one · 2017Article
- Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation andGut pathogens · 2017Article
- Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.Molecular cancer therapeutics · 2016Article
- Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis.The EMBO journal · 2016Article
- Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.Cell host & microbe · 2016Article
- The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments.Seminars in immunopathology · 2016Review
- Association between toll-like receptor 6 expression and auxiliary T cells in the peripheral blood of pediatric patients with allergic purpura.Experimental and therapeutic medicine · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-helper 1 and 17 (Th1/Th17) responses are important in inflammatory bowel disease (IBD), and research indicates that Toll-like receptor 6 (TLR6) stimulation leads to Th17 cell development within the lung. The gastrointestinal tract, like the lung, is a mucosal surface that is exposed to bacterially derived TLR6 ligands. Thus, we looked at the effects of TLR6 stimulation on the expression of Th17-, Th1-, and regulatory T-cell-associated transcription factors; RORγt, T-bet, and Foxp3, respectively; in CD4+ T cells within gut-associated lymphoid tissue (GALT) in vitro and in vivo. Cells from GALT and spleen were stimulated with anti-CD3 and TLR ligands for TLR1/2 and TLR2/6 (Pam3CSK4 and FSL-1, respectively). FSL-1 was more effective than Pam3CSK4 at inducing Th1 and Th17 responses in the GALT while Pam3CSK4 rivaled FSL-1 in the spleen. TLR6 was further explored in vivo using experimental colitis. Tlr6-/- mice were resistant to colitis, and oral FSL-1 led to more severe colitis in wild-type mice. Similar pro-inflammatory reactions were seen in human peripheral blood mononuclear cells, and TLR6 expression was directly correlated with RORC mRNA levels in inflamed intestines of IBD patients. These results demonstrate that TLR6 supports Th1- and Th17-skewed responses in the GALT and might be an important target for the development of new medical interventions in IBD.
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