ArticleParticle and fibre toxicology2014
Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells.
Article in Particle and fibre toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 109 citations in OpenAlex.
- Toxicity of respirable coal dust: An overview of origin, chemistry, mechanisms, and possible remedies.International journal of coal science & technology · 2026Review
- Computed tomography image analysis of cobalt oxide nanoparticles-induced cytopathic effect on Hep-G2 cell lines.RSC advances · 2025Article
- Nanotechnology in COVID-19 prevention, diagnosis, and treatment: a comprehensive review.Discover nano · 2025Review
- The predictive value of multiple urinary metals in evaluating death risk in asthmatic individuals: a prospective cohort study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- 3D printing: Balancing innovation for sustainability with emerging environmental and health risks.iScience · 2025Review
- ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials.Particle and fibre toxicology · 2024Article
- Exposure to urban nanoparticles at low PM[Formula: see text] concentrations as a source of oxidative stress and inflammation.Scientific reports · 2023Article
- Air pollution exposure and social responsiveness in childhood: The cincinnati combined childhood cohorts.International journal of hygiene and environmental health · 2023Article
- Cyto-Genotoxicity of Tritiated Stainless Steel and Cement Particles in Human Lung Cell Models.International journal of molecular sciences · 2022Article
- Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice.Archives of toxicology · 2021Article
- Exposure-based ecotoxicity assessment of CoEnvironmental science and pollution research international · 2021Article
- Femtosecond pulsed laser microscopy: a new tool to assess the in vitro delivered dose of carbon nanotubes in cell culture experiments.Particle and fibre toxicology · 2021Article
- Comparative Effects of Particle Sizes of Cobalt Nanoparticles to Nine Biological Activities.International journal of molecular sciences · 2020Article
- Bioaccessibility of Nickel and Cobalt Released from Occupationally Relevant Alloy and Metal Powders at Simulated Human Exposure Scenarios.Annals of work exposures and health · 2020Article
- LiCoOParticle and fibre toxicology · 2020Article
- Effects of PMParticle and fibre toxicology · 2020Article
- Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease.Journal of immunotoxicology · 2019Review
- Toxicological Assessment of ITER-Like Tungsten Nanoparticles Using an In Vitro 3D Human Airway Epithelium Model.Nanomaterials (Basel, Switzerland) · 2019Article
- HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles.Particle and fibre toxicology · 2019Article
- The impact of nanomaterial characteristics on inhalation toxicity.Toxicology research · 2018Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms of toxicity of metal oxide particles towards lung cells are far from being understood. In particular, the relative contribution of intracellular particulate versus solubilized fractions is rarely considered as it is very challenging to assess, especially for low-solubility particles such as cobalt oxide (Co3O4).
methodsThis study was possible owing to two highly sensitive, independent, analytical techniques, based on single-cell analysis, using ion beam microanalysis, and on bulk analysis of cell lysates, using mass spectrometry.
resultsOur study shows that cobalt oxide particles, of very low solubility in the culture medium, are readily incorporated by BEAS-2B human lung cells through endocytosis via the clathrin-dependent pathway. They are partially solubilized at low pH within lysosomes, leading to cobalt ions release. Solubilized cobalt was detected within the cytoplasm and the nucleus. As expected from these low-solubility particles, the intracellular solubilized cobalt content is small compared with the intracellular particulate cobalt content, in the parts-per-thousand range or below. However, we were able to demonstrate that this minute fraction of intracellular solubilized cobalt is responsible for the overall toxicity.
conclusionsCobalt oxide particles are readily internalized by pulmonary cells via the endo-lysosomal pathway and can lead, through a Trojan-horse mechanism, to intracellular release of toxic metal ions over long periods of time, involving specific toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.